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Dergiler / Turkish Journal of Medical Sciences / 1999 / Cilt: 29 - Sayı: 4

In vitro Effects of Some Anthelminthics on the Malate Dehydrogenase and Lactate Dehydrogenase Enzyme Activities of Taenia Saginata

A. Yasemin ÖZTOP
Gülendame SAYGI
H. Nursevin ÖZTOP
Sayfa
365–370
Yayın Tarihi
2022-11-04
DOI
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In vitro addition of albendazole and niclosamide increased the Vmax value of MDH, whereas it decreased Km value of MDH (p

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Amaç & Hipotez:Malate Dehydrogenase (MDH) and Lactate Dehydrogenase (LDH) activities were demonstrated in the mitochondrial and cytosolic fractions of an intestinal cestode, Taenia saginata, and then the in vitro effects of three anthelminthics, albendazole, niclosamide, and piperazine on these enzymes were investigated.
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Temel Bulgular & Veri:The Vmax and Km values of MDH were found to be 3.00 mmol (min mg protein) -1 and 0.0166 mM respectively.
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Sonuç & Katkı:In vitro addition of albendazole and niclosamide increased the Vmax value of MDH, whereas it decreased Km value of MDH (p
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Malate Dehydrogenase · Lactate Dehydrogenase · Taenia saginata

Özet

Malate Dehydrogenase (MDH) and Lactate Dehydrogenase (LDH) activities were demonstrated in the mitochondrial and cytosolic fractions of an intestinal cestode, Taenia saginata, and then the in vitro effects of three anthelminthics, albendazole, niclosamide, and piperazine on these enzymes were investigated. The Vmax and Km values of MDH were found to be 3.00 mmol (min mg protein) -1 and 0.0166 mM respectively. In vitro addition of albendazole and niclosamide increased the Vmax value of MDH, whereas it decreased Km value of MDH (p

Abstract

Malate Dehydrogenase (MDH) and Lactate Dehydrogenase (LDH) activities were demonstrated in the mitochondrial and cytosolic fractions of an intestinal cestode, Taenia saginata, and then the in vitro effects of three anthelminthics, albendazole, niclosamide, and piperazine on these enzymes were investigated. The Vmax and Km values of MDH were found to be 3.00 mmol (min mg protein) -1 and 0.0166 mM respectively. In vitro addition of albendazole and niclosamide increased the Vmax value of MDH, whereas it decreased Km value of MDH (p

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Bu Makaleye Atıf Yap

ÖZTOP, A. Y., SAYGI, G., ÖZTOP, H. N. (2022). In vitro Effects of Some Anthelminthics on the Malate Dehydrogenase and Lactate Dehydrogenase Enzyme Activities of Taenia Saginata. Turkish Journal of Medical Sciences, Cilt: 29 - Sayı: 4, 365–370. https://ajindex.com/articles/612480

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