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Journals / Turkish Journal of Medical Sciences / 1999 / Cilt: 29 - Sayı: 4

In vitro Effects of Some Anthelminthics on the Malate Dehydrogenase and Lactate Dehydrogenase Enzyme Activities of Taenia Saginata

A. Yasemin ÖZTOP
Gülendame SAYGI
H. Nursevin ÖZTOP
Pages
365–370
Publication Date
2022-11-04
DOI
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⚡ TL;DR(Too Long; Didn't Read)

In vitro addition of albendazole and niclosamide increased the Vmax value of MDH, whereas it decreased Km value of MDH (p

📌 3 Key Takeaways

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Objective & Hypothesis:Malate Dehydrogenase (MDH) and Lactate Dehydrogenase (LDH) activities were demonstrated in the mitochondrial and cytosolic fractions of an intestinal cestode, Taenia saginata, and then the in vitro effects of three anthelminthics, albendazole, niclosamide, and piperazine on these enzymes were investigated.
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Key Findings & Data:The Vmax and Km values of MDH were found to be 3.00 mmol (min mg protein) -1 and 0.0166 mM respectively.
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Conclusion & Impact:In vitro addition of albendazole and niclosamide increased the Vmax value of MDH, whereas it decreased Km value of MDH (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Malate Dehydrogenase · Lactate Dehydrogenase · Taenia saginata

Abstract

Malate Dehydrogenase (MDH) and Lactate Dehydrogenase (LDH) activities were demonstrated in the mitochondrial and cytosolic fractions of an intestinal cestode, Taenia saginata, and then the in vitro effects of three anthelminthics, albendazole, niclosamide, and piperazine on these enzymes were investigated. The Vmax and Km values of MDH were found to be 3.00 mmol (min mg protein) -1 and 0.0166 mM respectively. In vitro addition of albendazole and niclosamide increased the Vmax value of MDH, whereas it decreased Km value of MDH (p

Özet

Malate Dehydrogenase (MDH) and Lactate Dehydrogenase (LDH) activities were demonstrated in the mitochondrial and cytosolic fractions of an intestinal cestode, Taenia saginata, and then the in vitro effects of three anthelminthics, albendazole, niclosamide, and piperazine on these enzymes were investigated. The Vmax and Km values of MDH were found to be 3.00 mmol (min mg protein) -1 and 0.0166 mM respectively. In vitro addition of albendazole and niclosamide increased the Vmax value of MDH, whereas it decreased Km value of MDH (p

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Cite This Article

ÖZTOP, A. Y., SAYGI, G., ÖZTOP, H. N. (2022). In vitro Effects of Some Anthelminthics on the Malate Dehydrogenase and Lactate Dehydrogenase Enzyme Activities of Taenia Saginata. Turkish Journal of Medical Sciences, Cilt: 29 - Sayı: 4, 365–370. https://ajindex.com/articles/612480

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