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Dergiler / Turkish Journal of Chemistry / 2007 / Cilt: 31 - Sayı: 6

Synthesis of the amide derivatives of 3-(1-(3- pyridazinyl)-5-phenyl-1H-pyrazole-3-yl)propanoic acids as potential analgesic compounds

Murat ŞÜKÜROĞLU
Mustafa ARK
Erden BANOĞLU
Çalışkan Burcu ERGÜN
Nacak Sultan BAYTAŞ
Eda AYPAR
Sayfa
677–687
Yayın Tarihi
2022-11-05
DOI
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The results showed that the analgesic activity of 5a, 5f, 5n, and 5o is significantly higher than that of 5d.

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Amaç & Hipotez:A series of structurally diverse amide derivatives of 3-[1-(3-pyridazinyl)-5-phenyl-1H-pyrazole-3- yl]propanoic acids were prepared and tested for their in vivo analgesic activity using an acetic acid induced writhing test.
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Temel Bulgular & Veri:All the test compounds displayed approximately equipotent analgesic activity to aspirin.
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Sonuç & Katkı:The results showed that the analgesic activity of 5a, 5f, 5n, and 5o is significantly higher than that of 5d.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

A series of structurally diverse amide derivatives of 3-[1-(3-pyridazinyl)-5-phenyl-1H-pyrazole-3- yl]propanoic acids were prepared and tested for their in vivo analgesic activity using an acetic acid induced writhing test. All the test compounds displayed approximately equipotent analgesic activity to aspirin. The results showed that the analgesic activity of 5a, 5f, 5n, and 5o is significantly higher than that of 5d.

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Bu Makaleye Atıf Yap

ŞÜKÜROĞLU, M., ARK, M., BANOĞLU, E., ERGÜN, Ç. B., BAYTAŞ, N. S., AYPAR, E. (2022). Synthesis of the amide derivatives of 3-(1-(3- pyridazinyl)-5-phenyl-1H-pyrazole-3-yl)propanoic acids as potential analgesic compounds. Turkish Journal of Chemistry, Cilt: 31 - Sayı: 6, 677–687. https://ajindex.com/articles/602173

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Kaynakça (22)

  1. D. Clinch, A.K. Banerjee, G. Ostick and D.W. Levy, J.R. Coll. Physicians Lond. 17, 228-30 (1983)
  2. P. Brooks, P. Emery, J.F. Evans, H. Fenner, C.J. Hawkey, C. Patrono,J. Smo len, F. Breedveld, R. Day, M. Dougados, E.W. Ehrich, J. Gijon-Banos, T.K. Kvien, M.H. Van Rijswijk, T. Warner and H. Zeidler, Rheumatology, 38, 779-88 (1999)
  3. S. Leone, A. Ottani, and A. Bertolini, Curr. Topics Med. Chem., 7, 265-75 (2007)
  4. V. Dal Piaz, M.P. Giovannoni, G. Ciciani, D. Barlocco, G. Giardina, G. Petrone and G.D. Clarke, Eur. J. Med. Chem. 31, 65-70 (1996)
  5. P. Coudert, C. Rubat, F. Rohet, F. Leal, J. Fialip and J. Couquelet, Pharm. Pharmacol. Commun. 6, 387-96 (2000)
  6. V.K. Chintakunta, V. Akella, M.S. Vedula, P.K. Mamnoor, P. Mishra, S.R. Casturi, A. Vangoori and R. Rajagopalan, Eur. J. Med. Chem., 37, 339-47 (2002)
  7. M. Takaya, M. Sato, K. Terashima and H. Tanizawa, J. Med. Chem. 22, 53-58 (1979)
  8. D.S. Dogruer, M.F. Sahin, S. Ünlü and I. Shigeru, Arch. Pharm. Pharm. Med. Chem., 333, 79-86 (2000)
  9. A.S. Kalgutkar, A.B. Marnett, B.C. Crews, R.P. Remel and L.J. Marnett, J. Med. Chem. 43, 2860-70 (2000)
  10. A.S. Kalgutkar, S.W. Rowlinson, B.C. Crews and L.J. Marnett, Bioorg. Med. Chem. Lett. 12, 521-24 (2002)
  11. S. Moreau, P. Coudert, C. Rubat, E. Albuisson and J. Couquelet, Arzneim.-Forsch./Drug Res. 46, 800-05 (1996)
  12. B. Okçelik, S. Ünlü, E. Banoglu, E. Küpeli, E. Yesilada and M.F. Sahin, Arch. Pharm. Pharm. Med. Chem. 336, 406-12 (2003)
  13. S. Pieretti, V. Dal Piaz, R. Matucci, M.P. Giovannoni and A. Galli, Life Sci. 65, 1381-94 (1999)
  14. F. Rohet, C. Rubat, P. Coudert, E. Albuisson and J. Couquelet, Chem. Pharm. Bull. 44, 980-86 (1996)
  15. M.P. Wachter, 1993, U.S. Patent 5, 242, 940; A. Abdel-Magid, 2002, U.S. Patent 6, 384, 233; W.V. Murray, 1998, E.P. 0293221
  16. R. Koster, M. Anderson and E.J. Debeer, Fed. Proc. 18, 412-18 (1959)
  17. S. Altug, O. Uludag, B. Tunctan, I. Cakici, H. Zengil and N. Abacioglu, Chronobiol. Int. 23, 583-591 (2006)
  18. E. Banoglu, Ç. Akoglu, S. Unlu, E. Küpeli, E. Yesilada and M.F. Sahin, Arch. Pharm. Pharm. Med. Chem. 337, 7-14 (2004)
  19. C. Rubat, P. Coudert, P. Tronche, J. Bastide, P. Bastide and A.M. Privat, Chem. Pharm. Bull. 37, 2832-35 (1989)
  20. C. Rubat, P. Coudert, E. Albuisson, J. Bastide, J. Couquelet and P. Tronche, J. Pharm. Sci. 81, 1084-87 (1992)
  21. M. Gokce, D. Dogruer and M.F. Sahin, Farmaco 56, 233-37 (2001)
  22. K. Tsuji, K. Nakamura, N. Konishi, T. Tojo, T. Ochi, H. Senoh and M.