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Journals / Turkish Journal of Chemistry / 2007 / Cilt: 31 - Sayı: 6

Synthesis of the amide derivatives of 3-(1-(3- pyridazinyl)-5-phenyl-1H-pyrazole-3-yl)propanoic acids as potential analgesic compounds

Murat ŞÜKÜROĞLU
Mustafa ARK
Erden BANOĞLU
Çalışkan Burcu ERGÜN
Nacak Sultan BAYTAŞ
Eda AYPAR
Pages
677–687
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

The results showed that the analgesic activity of 5a, 5f, 5n, and 5o is significantly higher than that of 5d.

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Objective & Hypothesis:A series of structurally diverse amide derivatives of 3-[1-(3-pyridazinyl)-5-phenyl-1H-pyrazole-3- yl]propanoic acids were prepared and tested for their in vivo analgesic activity using an acetic acid induced writhing test.
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Key Findings & Data:All the test compounds displayed approximately equipotent analgesic activity to aspirin.
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Conclusion & Impact:The results showed that the analgesic activity of 5a, 5f, 5n, and 5o is significantly higher than that of 5d.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

A series of structurally diverse amide derivatives of 3-[1-(3-pyridazinyl)-5-phenyl-1H-pyrazole-3- yl]propanoic acids were prepared and tested for their in vivo analgesic activity using an acetic acid induced writhing test. All the test compounds displayed approximately equipotent analgesic activity to aspirin. The results showed that the analgesic activity of 5a, 5f, 5n, and 5o is significantly higher than that of 5d.

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Cite This Article

ŞÜKÜROĞLU, M., ARK, M., BANOĞLU, E., ERGÜN, Ç. B., BAYTAŞ, N. S., AYPAR, E. (2022). Synthesis of the amide derivatives of 3-(1-(3- pyridazinyl)-5-phenyl-1H-pyrazole-3-yl)propanoic acids as potential analgesic compounds. Turkish Journal of Chemistry, Cilt: 31 - Sayı: 6, 677–687. https://ajindex.com/articles/602173

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