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Dergiler / Turkish Journal of Chemistry / 2018 / Cilt: 42 - Sayı: 1

Hybrid organic molecules as antiin ammatory agents; a review of structural features and biological activity

Matloob AHMAD
Noor ul Amin MOHSIN
Sayfa
1–20
Yayın Tarihi
2022-11-05
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The preparation of new hybrid molecules is signi cant because they can serve as a lead compound for the discovery and development of safer analgesic and antiin ammatory agents.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Nonsteroidal antiin ammatory drugs (NSAIDs) are widely used for the treatment of pain and in ammation.
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Temel Bulgular & Veri:Combination of NSAIDs with different biologically active 5-membered, 6-membered, and condensed heterocyclic rings has also led to the formation of some potent molecules.
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Sonuç & Katkı:The preparation of new hybrid molecules is signi cant because they can serve as a lead compound for the discovery and development of safer analgesic and antiin ammatory agents.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Nonsteroidal antiin ammatory drugs (NSAIDs) are widely used for the treatment of pain and in ammation. Some undesirable effects are linked with NSAIDs such as the gastrointestinal tract (GIT) toxicity and cardiovascular disturbances. At present the preparation of a hybrid molecular technique is being used to produce new analgesic and antiin ammatory molecules. Attachment of NSAIDs with nitric oxide and hydrogen sul de releasing molecules produced some gastroprotective agents with improved analgesic and antiin ammatory activities. Combination of NSAIDs with different biologically active 5-membered, 6-membered, and condensed heterocyclic rings has also led to the formation of some potent molecules. Some of these hybrid molecules, e.g., ibuprofen{thiazole, exhibited less GIT toxicity, while others showed selectivity for COX-2 enzyme, e.g., quinazolinone{pyrimidine and benzothiophene{rhodanine hybrids. COX-2 selectivity was also exhibited by hybrids of NSAIDs with natural molecules such as salicylates{resveratrol, chromone{ oxindole, and chrysin{indole{pyrazole. The preparation of new hybrid molecules is signi cant because they can serve as a lead compound for the discovery and development of safer analgesic and antiin ammatory agents.

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Bu Makaleye Atıf Yap

AHMAD, M., MOHSIN, N. U. A. (2022). Hybrid organic molecules as antiin ammatory agents; a review of structural features and biological activity. Turkish Journal of Chemistry, Cilt: 42 - Sayı: 1, 1–20. https://ajindex.com/articles/601960

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Kaynakça (25)

  1. O'Neil, L. A. Nat. Rev. Drug Discov. 2006, 5, 549-563
  2. Iwasaki, A.; Medzhitov, R. Science (New York, N.Y.) 2010, 327, 291-295
  3. Rao, T. S., Currie, J. L., Shaffer, A. F., Isakson, P. C. In ammation 1993, 17, 723-741
  4. Reuter, S.; Gupta, S. C.; Chaturvedi, M. M.; Aggarwal, B. B. Free Radical Biol. Med. 2010, 49, 1603-1616
  5. Burian, M.; Geisslinger, G. Pharmacol. Therap. 2005, 107, 139-154
  6. Vane, V. R. Nat. New. Biol. 1971, 231, 232-235
  7. Allison, M. C., Howatson, A. G., Torrance, C. J., Lee, F. D., Russell, R. I. N. Engl. J. Med. 1992, 327, 749-754
  8. Schneider, V., Levesque, L. E., Zhang, B., Hutchinson, T., Brophy, J. M. Am. J. Epidemiol. 2006, 164, 881-889
  9. Zadrazil, J. Vnitr. Lek. 2006, 52, 686-690
  10. Lazzaroni, M., Bianchi Porro, G. Aliment. Pharmacol. Ther. 2004, 20, 48-58
  11. Vane, S. J. Thorax 2000, 55, S3-S9
  12. Johnsen, S. P., Larsson, H., Tarone, R. E., Mc Laughlin, J. K., Norgard, B., Friis, S., Sorensen, H. T. Arch. Intern. Med. 2005, 165, 978-984
  13. Melagraki, G., Afantitis, A., Igglessi-Markopoulou, O., Destsi, A., Koufaki, M., Kontogiorgis, C.; Hadjipavlou- Litina D. J. Eur. J. Med. Chem. 2009, 44, 3020-3026
  14. Wermuth, C. G. The Practice of Medicinal Chemistry (3rd ed.); Elsevier, New York, NY, USA, 2008
  15. Abbas, S. E.; Awadallah, F. M.; Ibrahin, N. A.; Said, E. G.; Kamel, G. M. Eur. J. Med. Chem. 2012, 53, 141-149
  16. Pawe lczyk, A.; Olender, D.; Sowa-Kasprzak, K.; Zaprutko, L. Molecules 2016, 21, 420
  17. Schnitzer, T.; Kivitz, A.; Frayssinet, H.; Duquesroix, B. Osteoarthr. Cartilage 2010, 18, 629-639
  18. Rainsford, K. D. Subcell. Biochem. 2007, 42, 3-27
  19. Kodela, R., Chattopadhyay, M., Kash, K. ACS Med. Chem. Lett. 2012, 3, 257-262
  20. Fonseca, M. D.; Cunha, F. Q.; Kash, K.; Cunha, T. M. Pharmacol. Res. Perspect. 2015, 3, e00133
  21. Turnbull, C. M.; Marcarino, P.; Sheldrake, T. A.; Lazzarato, L.; Cena, C.; Fruttero, R.; Gasco, A.; Fox, S.; Megson, I. L.; Rossi, A. G. J. In amm. (Lond) 2008, 5, 12
  22. Amir, M., Akhter, M. W., Somakala, K. Ind. J. Chem. 2016, 55B, 989-998
  23. Huang, Z.; Velazquez, C. A.; Abdellatif, K. R. A.; Chowdhury, M. A.; Reisz, J. A.; DuMond, J. F.; King, S. B.; Knaus, E. E. J. Med. Chem. 2011, 54, 1356-1364
  24. Bhandari, S. V.; Parikh, J. K.; Bothara, K. G.; Chitre, T. S.; Lokwani, D. K.; Devale, T. L.; Modhave, N. S.; Pawar, V. S.; Panda, S. J. Enzyme Inhib. Med. Chem. 2010, 25, 520-530
  25. Kash, K.; Chattopadhyay, M.; Ko