Compounds 3 and 5 exhibited antibacterial activity against all tested gram-positive bacteria.
📌 3 Maddede Bu Makale
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Amaç & Hipotez:2-Substituted 8-propargyloxyquinoline derivatives have been synthesized from 2-substituted-8-hydroxyquinolinesby O-propargylation method (30%–98% yields).
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Temel Bulgular & Veri:The maximum radical scavenging (46.5%) and reducing power activities were obtained from 1 and maximum ferrous chelating effect was obtainedfrom 6 (72.1%) at the concentration of 500 µg/mL.
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Sonuç & Katkı:Compounds 3 and 5 exhibited antibacterial activity against all tested gram-positive bacteria.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri
Abstract
2-Substituted 8-propargyloxyquinoline derivatives have been synthesized from 2-substituted-8-hydroxyquinolinesby O-propargylation method (30%–98% yields). The newly synthesized compounds were tested for in vitro antioxidantactivities such as DPPH radical scavenging, ferrous chelating, and reducing power activities. The maximum radical scavenging (46.5%) and reducing power activities were obtained from 1 and maximum ferrous chelating effect was obtainedfrom 6 (72.1%) at the concentration of 500 µg/mL. To indicate DNA binding activity of the complexes calf thymusDNA was used. The compounds were also evaluated for their antimicrobial activity against three gram-positive and threegram-negative bacteria. Compounds 3 and 5 exhibited antibacterial activity against all tested gram-positive bacteria.
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Bu Makaleye Atıf Yap
GÜMÜŞ, S., GÜMÜŞ, A., OKUMUŞ, V. (2022). Synthesis of 2-substituted 8-propargyloxyquinoline derivatives and determination of their antioxidant, antibacterial, and DNA binding activities. Turkish Journal of Chemistry, Cilt: 42 - Sayı: 5, 1358–1369. https://ajindex.com/articles/601788
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