Dergiler / Journal of Food and Health Science / 2017 / Cilt: 3 - Sayı: 1

HEPATOPROTECTIVE EFFECT OF TOFU PROCESSED FROM GERMINATED SOYBEAN ON CARBON TETRACHLORIDE INDUCED CHRONIC LIVER INJURY IN MICE

Sayfa
1–11
Yayın Tarihi
2022-10-18
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

It was suggested that tofu specially made from germinated soybeans expressed great hepatoprotective effect.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:The hepatoprotective activities of silk tofu made from germinated and non germinated soybeans at different doses of feeding against CCl4 induced hepatic cell toxicity in mice was investigated in this study.
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Temel Bulgular & Veri:All types of silk tofu significantly reduced the L/B value; ALT activity, total cholesterol, hepatic MDA and PC levels, beside, liver vitamin C content increased compared to CCl4 intoxicated mice.
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Sonuç & Katkı:It was suggested that tofu specially made from germinated soybeans expressed great hepatoprotective effect.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

The hepatoprotective activities of silk tofu made from germinated and non germinated soybeans at different doses of feeding against CCl4 induced hepatic cell toxicity in mice was investigated in this study. The heptatoprotective activity was analyzed by assessing the ratio of liver weight to body weight (L/B), the levels of serum alanine aminotransferase (ALT), total cholesterols (TC), the hepatic malondehydyde (MDA), protein carbonyl (PC) and vitamin C levels as well as the histopathological analysis of liver tissue. All types of silk tofu significantly reduced the L/B value; ALT activity, total cholesterol, hepatic MDA and PC levels, beside, liver vitamin C content increased compared to CCl4 intoxicated mice. Silk tofu made from germinated soybeans expressed higher hepatoprotective activity as compared to silk tofu made from non germinated soybeans. Mice fed with silk tofu made from germinated soybeans at the dose of 0.4 g/g body weight/day displayed all biochemical parameters as well as the liver tissue histopathological analysis that were similar to that of normal mice and silymarin treated mice. It was suggested that tofu specially made from germinated soybeans expressed great hepatoprotective effect.

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Bu Makaleye Atıf Yap

HOANG, C. T. K., HANH, N. T., CHU, D. X., TRAM, P. T. B., TOAN, H. T., LİEN1, D. T. P. (2022). HEPATOPROTECTIVE EFFECT OF TOFU PROCESSED FROM GERMINATED SOYBEAN ON CARBON TETRACHLORIDE INDUCED CHRONIC LIVER INJURY IN MICE. Journal of Food and Health Science, Cilt: 3 - Sayı: 1, 1–11. https://ajindex.com/articles/563425

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Kaynakça (9)

  1. Abdel-Wahhab, K.G.E.-D., El-Shamy, K.A., El- Beih, N.A.E.-Z., Morcy, F.A. & Mannaa, F.A.E. (2011). Protective effect of a natural herb (Rosmarinus officinalis) against hepatotoxicity in male albino rats. Comunicata Scientiae, 2(1), 9-17.
  2. Abdel-Wahhab, M.A., Ahmed, H. & Hagazi, M.M. (2006). Prevention of aflatoxin B1- initiated hepatotoxicity in rat by marine algae extracts. Journal, 26(3), 229-238. doi: 10.1002/jat.1127. Al-Assaf, A.H. (2014). Efficacy of corosolic and acid on mitochondrial enzymes and DNA damage against CCl4-induced heptatoxic rats. JAPS, Journal of Animal and Plant Sciences, 24(5), 1366-1373.
  3. Ashraf, J., Nagma, J.S., Mirani, N. & Rub, A. (2012). Protective effect of rutin against carbon tetrachloride-induced hepatotoxicity in mice. International Journal of Drug Development and Research, 4(2), 352-357.
  4. Boll, M., Weber, L.W., Becker, E. & Stampfl, A. (2001). Pathogenesis of carbon tetrachloride-induced hepatocyte injury bioactivation of CCl4 by cytochrome P450 and effects on lipid homeostasis. Zeitschrift für Naturforschung, 56(1-2), 111-121.
  5. Bradford, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry, 72(1-2), 248-254.
  6. Dalle-Donne, I., Rossi, R., Giustarini, D., Milzani, A. & Colombo, R. (2003). Protein carbonyl groups as biomarkers of oxidative stress. Clinica Chimica Acta, 329(1), 23-38.
  7. Domitrovic, R., Jakovac, H., Tomac, J. & Sain, I. (2009). Liver fibrosis in mice induced by carbon tetrachloride and its reversion by luteolin. Pharmacology, 241(3), 311-321.
  8. Duong, T.P.L., Phan, T.B.T. & Ha, T.T. (2015). Chemical composition and antioxidant activity of different soybean cultivars from Mekong river delta - Vietnam. International Journal of Engineering Sciences & Research Technology, 4(11), 321-326.
  9. El Denshary, E.S., Al-Gahazali, M.A., Mannaa, F.A., Salem, H.A., Hassan, N.S. & Abdel- Wahhab, M.A. (2012). Dietary honey and ginseng tetrachloride-induced hepatonephrotoxicity in rats. Experimental and Toxicologic Pathology, 64(7), 753-760. carbon Essawy, A.E., Abdel-Moneim, A.M., Khayyat, L.I. & Elzergy, A.A. (2012). Nigella sativa seeds protect against hepatotoxicity and dyslipidemia tetrachloride in mice. Journal of Applied Pharmaceutical Science, 2(10), 21-25. doi: 10.7324/JAPS.2012.21004 by carbon Fernandez-Orozco, R., Frias, J., Zielinski, H., Piskula, M.K., Kozlowska, H. & Vidal- Valverde, C. (2008). Kinetic study of