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Dergiler / İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi / 2017 / Cilt: 24 - Sayı: 1

The possible hepatoprotective effect of apricot against acrylamide induced hepatotoxicity in rats

Mehmet Erman ERDEMLİ
Nurhan ŞAHİN
Yusuf TURKOZ
Ismet YİLMAZ
Muslum AKGOZ
Kamuran CİNAR
Yilmaz CİGREMİS
Sayfa
48–53
Yayın Tarihi
2022-10-17
DOI
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There were no significant differences between the groups based on GST activity, histopathological results and GST-Pi gene expression mRNA levels (p < 0.05).Conclusion: It could be stated that acrylamide, at approximately 500 μg/kg/day, ingested by rats were detoxified by the liver without resulting any liver tissue damage and application of acrylamide with sun-dried organic apricot did not change any significant molecular, histopathological and biochemical parameters in the liver.

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Amaç & Hipotez:Objective: The aim of this study was to investigate the possible toxic effects of sub-chronic doses of acrylamide taken withdrinking water on liver tissue and to test the preventive role of 5% organic dried apricot as diet supplement, in female SpragueDawley rats.Materials and Methods: Forty female Spraque Dawley rats were divided into 4 equal groups as follows: control group (C) animals were fed with normal rat chow and tap water, apricot group (A) animals were fed with chow contain %5 apricot and tap water, acrylamide group (AA) animals were fed with normal rat chow and acrylamide at approximately 500 μg/kg/day via tap water, acrylamide+apricot group (AA+A) animals were fed with chow contain 5% apricot and approximately 500 μg/kg/day acrylamide via drinking water.
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Temel Bulgular & Veri:The study procedure was maintained during 12 weeks experiment period.
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Sonuç & Katkı:There were no significant differences between the groups based on GST activity, histopathological results and GST-Pi gene expression mRNA levels (p < 0.05).Conclusion: It could be stated that acrylamide, at approximately 500 μg/kg/day, ingested by rats were detoxified by the liver without resulting any liver tissue damage and application of acrylamide with sun-dried organic apricot did not change any significant molecular, histopathological and biochemical parameters in the liver.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Objective: The aim of this study was to investigate the possible toxic effects of sub-chronic doses of acrylamide taken withdrinking water on liver tissue and to test the preventive role of 5% organic dried apricot as diet supplement, in female SpragueDawley rats.Materials and Methods: Forty female Spraque Dawley rats were divided into 4 equal groups as follows: control group (C) animals were fed with normal rat chow and tap water, apricot group (A) animals were fed with chow contain %5 apricot and tap water, acrylamide group (AA) animals were fed with normal rat chow and acrylamide at approximately 500 μg/kg/day via tap water, acrylamide+apricot group (AA+A) animals were fed with chow contain 5% apricot and approximately 500 μg/kg/day acrylamide via drinking water. The study procedure was maintained during 12 weeks experiment period. At the end of the study, samples of liver tissue were collected for biochemical, histopathological and molecular analyses.Results: In this study, comparison of acrylamide group liver tissue GSH levels and GSH-Px activities were found lower whencompared to the control group (p < 0.05). There were no significant differences between the groups based on GST activity, histopathological results and GST-Pi gene expression mRNA levels (p < 0.05).Conclusion: It could be stated that acrylamide, at approximately 500 μg/kg/day, ingested by rats were detoxified by the liver without resulting any liver tissue damage and application of acrylamide with sun-dried organic apricot did not change any significant molecular, histopathological and biochemical parameters in the liver.

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Bu Makaleye Atıf Yap

ERDEMLİ, M. E., ŞAHİN, N., TURKOZ, Y., YİLMAZ, I., AKGOZ, M., CİNAR, K., CİGREMİS, Y. (2022). The possible hepatoprotective effect of apricot against acrylamide induced hepatotoxicity in rats. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi, Cilt: 24 - Sayı: 1, 48–53. https://ajindex.com/articles/549146

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Kaynakça (13)

  1. Bowyer JF, Latendresse JR, Delongchamp RR, Warbritton AR, Thomas M, Divine B, et al. The mRNA expression and histological integrity in rat forebrain motor and sensory regions are minimally affected by acrylamide exposure through drinking water. Toxicol Appl Pharmacol 2009;240(3):401-11.
  2. Bowyer JF, Latendresse JR, Delongchamp RR, Muskhelishvili L, Warbritton AR, Thomas M et al. The effects of subchronic acrylamide exposure on gene expression, neurochemistry, hormones, and histopathology in the hypothalamus-pituitary-thyroid axis of male Fischer 344 rats. Toxicol Appl Pharmacol 2008;230(2): 208-15.
  3. Mei N, Guo L, Tseng J, Dial SL, Liao W, Manjanatha MG. Gene expression changes associated with xenobiotic metabolism pathways in mice exposed to acrylamide. Environ Mol Mutagen 2008; 49(9):741–5.
  4. Zhu YJ, Zeng T, Zhu YB, Yu SF, Wang QS, Zhang LP, et al. Effects of acrylamide on the nervous tissue antioxidant system and sciatic nerve electrophysiology in the rat. Neurochem Res 2008;33(11):2310-7.
  5. Catalgol B, Ozhan G, Alpertunga B. Acrylamide-induced oxidative stress in human erythrocytes. Hum Exp Toxicol 2009;28(10):611–7.
  6. Erdemli ME, Doğan Z, Çiğremiş Y, Akgöz M, Altınöz E, Geçer M et al. Amelioration of subchronic acrylamide toxicity in large intestine of rats by organic dried apricot intake. Turk J Biol 2015;39:872-8.
  7. Awasthi YC, Singh SV, Goel SK, Reddy JK. Irreversibl inhibition of hepatic glutathione S-transferase by ciprofibrate, peroxisome proliferator.Biochem Biophys Res Commun 1984;123(3):1012–8.
  8. Moody DE, Narloch BA, Shull LR, Hammock BD. The effect of structually divergent herbicides on mouse liver xenobiotic-metabolizing enzymes (P-450-dependent mono-oxygenases, epoxide hydrolases and glutathione S-transferases) and carnitine acetyltranferase. Toxicol Lett 1991;59(1-3):175–85.
  9. Davies MH, Schnell RC. Comparison of basal glutathione S-transferase activities and of the influence of phénobarbital, butylated hydroxy-anisole or 5,5'- diphenylhydantoin on enzyme activity in male rodents. Comp Biochem Physiol C 1987;88(1):91-3.
  10. Dixit R, Husain R, Mukhtar H, Seth PK. Acrylamide induced inhibition of hepatic glutathione-S-transferase activity in rats. Toxicol Lett 1981;7(3):207-10.
  11. Awad ME, Abdel-Rahman MS, Hassan SA. Acrylamide toxicity in isolated rat hepatocytes. Toxicol in Vitro 1998;12(6):699-704.
  12. Yousef MI, El-Demerdash FM. Acrylamide-induced oxidative stress and biochemical perturbations in rats. Toxicology 2006;219(1-3):133-41.
  13. Van Lieshout EM, Bedaf MM,