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Journals / İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi / 2017 / Cilt: 24 - Sayı: 1

The possible hepatoprotective effect of apricot against acrylamide induced hepatotoxicity in rats

Mehmet Erman ERDEMLİ
Nurhan ŞAHİN
Yusuf TURKOZ
Ismet YİLMAZ
Muslum AKGOZ
Kamuran CİNAR
Yilmaz CİGREMİS
Pages
48–53
Publication Date
2022-10-17
DOI
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⚡ TL;DR(Too Long; Didn't Read)

There were no significant differences between the groups based on GST activity, histopathological results and GST-Pi gene expression mRNA levels (p < 0.05).Conclusion: It could be stated that acrylamide, at approximately 500 μg/kg/day, ingested by rats were detoxified by the liver without resulting any liver tissue damage and application of acrylamide with sun-dried organic apricot did not change any significant molecular, histopathological and biochemical parameters in the liver.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of this study was to investigate the possible toxic effects of sub-chronic doses of acrylamide taken withdrinking water on liver tissue and to test the preventive role of 5% organic dried apricot as diet supplement, in female SpragueDawley rats.Materials and Methods: Forty female Spraque Dawley rats were divided into 4 equal groups as follows: control group (C) animals were fed with normal rat chow and tap water, apricot group (A) animals were fed with chow contain %5 apricot and tap water, acrylamide group (AA) animals were fed with normal rat chow and acrylamide at approximately 500 μg/kg/day via tap water, acrylamide+apricot group (AA+A) animals were fed with chow contain 5% apricot and approximately 500 μg/kg/day acrylamide via drinking water.
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Key Findings & Data:The study procedure was maintained during 12 weeks experiment period.
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Conclusion & Impact:There were no significant differences between the groups based on GST activity, histopathological results and GST-Pi gene expression mRNA levels (p < 0.05).Conclusion: It could be stated that acrylamide, at approximately 500 μg/kg/day, ingested by rats were detoxified by the liver without resulting any liver tissue damage and application of acrylamide with sun-dried organic apricot did not change any significant molecular, histopathological and biochemical parameters in the liver.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study was to investigate the possible toxic effects of sub-chronic doses of acrylamide taken withdrinking water on liver tissue and to test the preventive role of 5% organic dried apricot as diet supplement, in female SpragueDawley rats.Materials and Methods: Forty female Spraque Dawley rats were divided into 4 equal groups as follows: control group (C) animals were fed with normal rat chow and tap water, apricot group (A) animals were fed with chow contain %5 apricot and tap water, acrylamide group (AA) animals were fed with normal rat chow and acrylamide at approximately 500 μg/kg/day via tap water, acrylamide+apricot group (AA+A) animals were fed with chow contain 5% apricot and approximately 500 μg/kg/day acrylamide via drinking water. The study procedure was maintained during 12 weeks experiment period. At the end of the study, samples of liver tissue were collected for biochemical, histopathological and molecular analyses.Results: In this study, comparison of acrylamide group liver tissue GSH levels and GSH-Px activities were found lower whencompared to the control group (p < 0.05). There were no significant differences between the groups based on GST activity, histopathological results and GST-Pi gene expression mRNA levels (p < 0.05).Conclusion: It could be stated that acrylamide, at approximately 500 μg/kg/day, ingested by rats were detoxified by the liver without resulting any liver tissue damage and application of acrylamide with sun-dried organic apricot did not change any significant molecular, histopathological and biochemical parameters in the liver.

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Cite This Article

ERDEMLİ, M. E., ŞAHİN, N., TURKOZ, Y., YİLMAZ, I., AKGOZ, M., CİNAR, K., CİGREMİS, Y. (2022). The possible hepatoprotective effect of apricot against acrylamide induced hepatotoxicity in rats. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi, Cilt: 24 - Sayı: 1, 48–53. https://ajindex.com/articles/549146

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