Journals / İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi / 2000 / Cilt: 7 - Sayı: 2

The effects of vitamin E and C combination on hyperbaric oxygen-induced lung toxicity in rats

Hiperbarik oksijenin sıçan solunum sisteminde oluşturduğu değişikliklerde vitamin E ve C kombinasyonunun etkisi

Pages
153–157
Publication Date
2022-11-05
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

Conclusions: It is concluded that vitamin E and C have positive effect on limiting the tissue damage caused by HBO.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: We examined the histopathological changes in the respiratory system of the rats induced by hyperbaric oxygen (HBO) administration and the effects of vitamin E and C on these alterations, Materials and Methods: Thirty adult rats were divided into three groups as control, HBO and HBO + Vit groups.
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Key Findings & Data:Twenty animals in HBO and HBO + Vit groups were exposed to HBO on a daily basis for 45 days.
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Conclusion & Impact:Conclusions: It is concluded that vitamin E and C have positive effect on limiting the tissue damage caused by HBO.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: We examined the histopathological changes in the respiratory system of the rats induced by hyperbaric oxygen (HBO) administration and the effects of vitamin E and C on these alterations, Materials and Methods: Thirty adult rats were divided into three groups as control, HBO and HBO + Vit groups. Twenty animals in HBO and HBO + Vit groups were exposed to HBO on a daily basis for 45 days. Additionally, vitamin E and C were administered to the rats in the HBO + Vit group intraperitoneally during HBO exposure. Results: Histologic examination in HBO group demonstrated epithelial thickening in the trachea, increase in the thickness of alveolar septae, emphysema and mononuclear cell infiltration in lung tissue. Vitamin administration in addition to HBO seemed to reduce the negative effects of HBO on the trachea and lungs of the rats. Conclusions: It is concluded that vitamin E and C have positive effect on limiting the tissue damage caused by HBO.

Özet

Amaç: Bu çalışmada, sıçan solunum sisteminde hiperbarik oksijen (HBO) uygulamasıyla oluşan yapısal değişiklikler ve bu değişikliklere E ve C vitaminlerinin etkileri araştırıldı. Materyal ve Metot: Otuz yetişkin sıçan, kontrol, HBO ve HBO + Vit grupları şeklinde üç ayrı grupta incelendi. HBO ve HBO + Vit gruplarına 45 gün süreyle HBO uygulandı; HBO + Vit grubuna ise ek olarak intraperitoneal yoldan E ve C vitaminleri verildi. Bulgular: HBO grubuna ait dokuların histolojik incelemelerinde, trakeada epitel kalınlaşması, akciğerde ise alveoler septumda kalınlaşma, amfizem ve mononükleer hücre infiltrasyonları izlendi. HBO ile beraber vitamin uygulamasının trakea ve akciğerde oluşan olumsuz etkileri azalttığı gözlendi. Sonuç: E ve C vitamin kombinasyonunun HBO'ya bağlı gelişen trakea ve akciğer doku hasarını azaltmada etkili olabileceği sonucuna varıldı.

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Cite This Article

KARAÖZ, E., KIBRISLI, E., YAĞMURCA, M., IRMAK, M. K., GÖKIRMAK, M. (2022). The effects of vitamin E and C combination on hyperbaric oxygen-induced lung toxicity in rats. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi, Cilt: 7 - Sayı: 2, 153–157. https://ajindex.com/articles/651950

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