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Dergiler / Annals of Medical Research / 2022 / Cilt: 29 - Sayı: 4

Effects of acrylamide and crocin on rat lung tissue

Harika Gözde GÖZÜKARA BAĞ
Zeynep ERDEMLİ
Mehmet Erman ERDEMLİ
Eyüp ALTINÖZ
Sayfa
397–400
Yayın Tarihi
2022-10-12
DOI
—
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Against AA toxicity, we recommend the consumption of Cr to improve antioxidant capacity.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Aim: We aimed to determine the effects of acrylamide (AA) and crocin (Cr) on rat lung tissues.
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Temel Bulgular & Veri:Rats were administered 25 mg/kg AA and 50 mg/kg Cr for 21 days.
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Sonuç & Katkı:Against AA toxicity, we recommend the consumption of Cr to improve antioxidant capacity.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Aim: We aimed to determine the effects of acrylamide (AA) and crocin (Cr) on rat lung tissues. Materials and Methods: Forty Wistar albino rats were divided into control, AA, Cr, and AA + Cr groups. Rats were administered 25 mg/kg AA and 50 mg/kg Cr for 21 days. After 21 days, malondialdehyde (MDA), reduced glutathione (GSH), total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), superoxide dismutase (SOD), catalase (CAT) and protein levels were measured in rat lung tissues. Results: The analysis of the rat lung tissues revealed that oxidant parameter markers (MDA, TOS, OSI) increased and antioxidant parameter markers (GSH, TAS, SOD, CAT) decreased in the AA group when compared to all other groups (p < 0.05). A significant increase was determined in antioxidant capacity (GSH, TAS, SOD, CAT) in the Cr-treatment group when compared to all other groups (p < 0.05). We found a significant improvement in oxidant-antioxidant parameters in the AA + Cr group when compared to the AA group (p < 0.05). Conclusion: This study was the first of its kind in the literature and revealed that AA administration led to damages in lung tissue. It could be suggested that this was due to an increase in oxidant levels and oxidative stress. Cr exerted a powerful antioxidant effect in lung tissues. Against AA toxicity, we recommend the consumption of Cr to improve antioxidant capacity.

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Bu Makaleye Atıf Yap

BAĞ, H. G. G., ERDEMLİ, Z., ERDEMLİ, M. E., ALTINÖZ, E. (2022). Effects of acrylamide and crocin on rat lung tissue. Annals of Medical Research, Cilt: 29 - Sayı: 4, 397–400. https://ajindex.com/articles/445600

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