KaydedilenlerDerginizi ekleyin

Dergiler / Hittite Journal of Science and Engineering / 2021 / Cilt: 8 - Sayı: 2

Isatis Glauca Subsp. Sivasica Extract Contributes to Diabetic Wound Healing Process via Increased Collagen and Nitric Oxide Content

Şule Coşkun Cevher
Kaan Kaltalıoğlu
Sayfa
141–147
Yayın Tarihi
2022-10-18
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

These data suggest that, for the first time, I. glauca subsp. sivasica extract may have the potential to promote the impaired wound healing in patients with diabetes.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Isatis L. genus highly endemic and that is traditionally suggested for wound management in Turkey.
📊
Temel Bulgular & Veri:A diabetic model was generated in Wistar rats using streptozotocin injection.
💡
Sonuç & Katkı:These data suggest that, for the first time, I. glauca subsp. sivasica extract may have the potential to promote the impaired wound healing in patients with diabetes.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:collagen · diabetes mellitus · Isatis glauca subsp. sivasica

Abstract

Isatis L. genus highly endemic and that is traditionally suggested for wound management in Turkey. In this study, we have reported the effect of I. glauca subsp. sivasica extract on diabetic wound healing process. A diabetic model was generated in Wistar rats using streptozotocin injection. Rats were divided into two main groups: control group and Isatis group. Full thickness excisional skin wounds were created by using a biopsy punch. The Isatis group was treated with single daily dose I. glauca subsp. sivasica extract (50 mg/kg). Rats were sacrificed day 3 or 7 after wounding. The dominant phenolic compounds identified with RP-HPLC-DAD from Isatis extract were the benzoic acid and vanillic acid. Isatis extract significantly accelerated wound healing process considering the wound closure rates (WCR). Moreover, the levels of collagen and nitric oxide were elevated on days 3 and 7 by Isatis administration in the diabetic wound tissue. These data suggest that, for the first time, I. glauca subsp. sivasica extract may have the potential to promote the impaired wound healing in patients with diabetes.

🔖

Bu Makaleye Atıf Yap

Cevher, Ş. C., Kaltalıoğlu, K. (2022). Isatis Glauca Subsp. Sivasica Extract Contributes to Diabetic Wound Healing Process via Increased Collagen and Nitric Oxide Content. Hittite Journal of Science and Engineering, Cilt: 8 - Sayı: 2, 141–147. https://ajindex.com/articles/537888

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (12)

  1. Güner A, Aslan S, Ekim T, Vural M, Babaç MT. Türkiye Bitkileri Listesi (Damarlı Bitkiler), first ed. Flora Araştırmaları Derneği ve Nezahat Gökyiğit Botanik Bahçesi Yayını, İstanbul, 2012.
  2. Yıldız N, Karakaş Ö. Qualitative and Quantitative Determination of Tryptanthrin, Indirubin, Indican and Isatin Indole Alkaloids During Vegetative and Flowering Stages in the Roots and Leaves of Isatis constricta P. H. Davis. Tarla Bitkileri Merkez Araştırma Enstitüsü Dergisi 28 (2019) 59–66.
  3. Karakoca K, Özüsağlam MA, Çakmak YS, Erkul SK. Antioxidative, antimicrobial and cytotoxic properties of isatis floribunda boiss. ex bornm. Extracts. EXCLI Journal 12 (2013) 150–167.
  4. Küpeli E, Orhan İ, Yeşilada E. Evaluation of Some Plants Used in Turkish Folk Medicine for Their Anti-inflammatory and Antinociceptive Activities. Pharmaceutical Biology 45 (2007) 547–555. Hamburger M. Isatis tinctoria - From the Rediscovery of an Ancient Medicinal Plant Towards a Novel Anti-Inflamatory Phytopharmaceutical. Phytochemistry Reviews 1 (2002) 333–344.
  5. Tuzlacı E, Doğan A. Turkish folk medicinal plants, IX: Ovacık (Tunceli). Marmara Pharmaceutical Journal 14 (2010) 136–143.
  6. Rezaeipoor R, Ziaei Sanei L, Kamalinejad M. Effects of Isatis cappadocica on humoral immune responses. Fitoterapia 71 (2000) 14-18.
  7. Ozturk M, Uysal I, Gucel S, Altundag E, Dogan Y, Baslar S. Medicinal Uses of Natural Dye-Yielding Plants in Turkey. Research Journal of Textile and Apparel 17 (2013) 69–80. Baytop T. Therapy with Plants in Turkey (Past & Present), second ed. Nobel Tıp, İstanbul, 1999.
  8. Guo S, DiPietro LA. Factors Affecting Wound Healing. Journal of Dental Research 89 (2010) 219–229.
  9. Li H, Fu X, Zhang L, Huang Q, Wu Z, Sun T. Research of PDGF-BB gel on the wound healing of diabetic rats and its pharmacodynamics. J Surg Res 145 (2008) 41–48.
  10. Kaltalioglu K, Balabanli B, Coskun-Cevher S. Phenolic, Antioxidant, Antimicrobial, and In-vivo Wound Healing Properties of Potentilla erecta L. Root Extract in Diabetic Rats. Iranian Journal of Pharmaceutical Research 19 (2020) 264–274. Brett D. A review of collagen and collagen-based wound dressings. Wounds 20 (2008) 347–356. Schäfer M, Werner S. Oxidative stress in normal and impaired wound repair. Pharmacol Res 58 (2008) 165–171.
  11. Blakytny R, Jude E. The molecular biology of chronic wounds and delayed healing in diabetes. Diabet Med 23 (2006) 594–608.
  12. Malone-Povolny MJ, Maloney SE, Schoenfisch MH. Nitric Oxide Therapy for Diabetic Wound Healing. Adv Healthc Mater 8 (2019) e18