KaydedilenlerDerginizi ekleyin

Dergiler / Annals of Medical Research / 2020 / Cilt: 27 - Sayı: 4

Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures

Ibrahim YİLMAZ
Ozkan ATES
Onur YAMAN
Numan KARAARSLAN
Yasin Emre KAYA
Duygu YAŞAR SİRİN
Hanefi OZBEK
Sayfa
1082–1087
Yayın Tarihi
2022-10-12
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The results obtained were statistically significant (P < 0.05).Conclusion: Although tigecycline had no toxic effect on the chondrocyte cell cultures and caused no damage to the extracellular matrix, the present study was performed in an in vitro environment.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:AbstractAim: Although antibiotics are generally well-tolerated, they may have cytotoxic effects.
📊
Temel Bulgular & Veri:The present randomized, double-blind, in vitro study aimed to investigate the effects of tigecycline on cartilage tissue cells and the extracellular matrix.Material and Methods: Cartilage tissues of patients (n = 8) were used for the preparation of primary cell cultures.
💡
Sonuç & Katkı:The results obtained were statistically significant (P < 0.05).Conclusion: Although tigecycline had no toxic effect on the chondrocyte cell cultures and caused no damage to the extracellular matrix, the present study was performed in an in vitro environment.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

AbstractAim: Although antibiotics are generally well-tolerated, they may have cytotoxic effects. The present randomized, double-blind, in vitro study aimed to investigate the effects of tigecycline on cartilage tissue cells and the extracellular matrix.Material and Methods: Cartilage tissues of patients (n = 8) were used for the preparation of primary cell cultures. Tigecycline-treated cell cultures served as the study group. Non-treated cell cultures served as the control group. Analyses were performed at 0, 24, 48, and 72 h in both groups. The results obtained were statistically evaluated. The alpha significance value was determined to be 0.05.Results: Proliferation remained unchanged in the tigecycline-treated cell cultures. The gene expressions of the markers involved in anabolic pathways increased in the tigecycline-treated cell cultures. The results obtained were statistically significant (P < 0.05).Conclusion: Although tigecycline had no toxic effect on the chondrocyte cell cultures and caused no damage to the extracellular matrix, the present study was performed in an in vitro environment.

🔖

Bu Makaleye Atıf Yap

YİLMAZ, I., ATES, O., YAMAN, O., KARAARSLAN, N., KAYA, Y. E., SİRİN, D. Y., OZBEK, H. (2022). Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures. Annals of Medical Research, Cilt: 27 - Sayı: 4, 1082–1087. https://ajindex.com/articles/446443

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (13)

  1. Karaarslan N, Yilmaz I, Ozbek H, et al. Is implant washing and wound irrigation with rifampicin effective for preventing surgical site infections in lumbar instrumentation? Turk Neurosurg 2018;28:904-909
  2. Dogan M, Isyar M, Yilmaz I, et al. Are the leading drugs against Staphylococcus aureus really toxic to cartilage? J Infect Public Health 2016;9:251-258
  3. Bilir B, Isyar M, Yilmaz I, et al. Evaluation of neutrophilto-lymphocyte ratio as a marker of inflammatory response in septic arthritis. Eur J Inflam 2015;3:196- 203
  4. Isyar M, Dogan M, Gumustas SA, et al. Evaluation of antibiotic alternatives used in orthopedic departments of 2 hospitals according to rational use of antibiotics. South Clin Ist Euras 2016;27:116-22
  5. Ranjbar R, Fatahian Kelishadrokhi A, Chehelgerdi M. Molecular characterization, serotypes and phenotypic and genotypic evaluation of antibiotic resistance of the Klebsiella pneumoniae strains isolated from different types of hospital-acquired infections. Infect Drug Resist 2019;20:603-11
  6. Srinivas NR. Tigecycline and cyclosporine interactionan interesting case of biliary-excreted drug enhancing the oral bioavailability of cyclosporine. Eur J Clin Pharmacol 2009;65:543-4
  7. Chen Y, Zhu D, Zhang Y, et al. A multicenter, doubleblind, randomized, comparison study of the efficacy and safety of tigecycline to imipenem/cilastatin to treat complicated intra-abdominal infections in hospitalized subjects in China. Ther Clin Risk Manag 2018;14:2327-39
  8. Kadoyama K, Sakaeda T, Tamon A, Okuno Y. Adverse event profile of tigecycline: data mining of the public version of the U.S. Food and Drug Administration adverse event reporting system. Biol Pharm Bull 2012;35:967-70
  9. Oznam K, Sirin DY, Yilmaz I, et al. Iopromide- and gadopentetic acid-derived preparates used in MR arthrography may be harmful to chondrocytes. J Orthop Surg Res 2017;12:98
  10. Muralidharan G, Micalizzi M, Speth J, et al. Pharmacokinetics of tigecycline after single and multiple doses in healthy subjects, Antimicrob Agents Chemother 2005;49:220-9
  11. Kaplan N, Yilmaz I, Karaarslan N, et al. Evaluation of the effect of daptomycin, a glycopeptide agent, on intact intervertebral disc tissue. Turk Neurosurg 2019;29:522-9
  12. Kaplan N, Karaarslan N, Yilmaz I, et al. Are intervertebral disc tissue cells damaged when attempting to prevent thrombus formation using dabigatran, a new oral anticoagulant? Turk Neurosurg 2019;29:470-7
  13. Kaya YE, Karaarslan N, Sirin DY, et al.