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Journals / Annals of Medical Research / 2020 / Cilt: 27 - Sayı: 4

Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures

Ibrahim YİLMAZ
Ozkan ATES
Onur YAMAN
Numan KARAARSLAN
Yasin Emre KAYA
Duygu YAŞAR SİRİN
Hanefi OZBEK
Pages
1082–1087
Publication Date
2022-10-12
DOI
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The results obtained were statistically significant (P < 0.05).Conclusion: Although tigecycline had no toxic effect on the chondrocyte cell cultures and caused no damage to the extracellular matrix, the present study was performed in an in vitro environment.

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Objective & Hypothesis:AbstractAim: Although antibiotics are generally well-tolerated, they may have cytotoxic effects.
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Key Findings & Data:The present randomized, double-blind, in vitro study aimed to investigate the effects of tigecycline on cartilage tissue cells and the extracellular matrix.Material and Methods: Cartilage tissues of patients (n = 8) were used for the preparation of primary cell cultures.
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Conclusion & Impact:The results obtained were statistically significant (P < 0.05).Conclusion: Although tigecycline had no toxic effect on the chondrocyte cell cultures and caused no damage to the extracellular matrix, the present study was performed in an in vitro environment.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

AbstractAim: Although antibiotics are generally well-tolerated, they may have cytotoxic effects. The present randomized, double-blind, in vitro study aimed to investigate the effects of tigecycline on cartilage tissue cells and the extracellular matrix.Material and Methods: Cartilage tissues of patients (n = 8) were used for the preparation of primary cell cultures. Tigecycline-treated cell cultures served as the study group. Non-treated cell cultures served as the control group. Analyses were performed at 0, 24, 48, and 72 h in both groups. The results obtained were statistically evaluated. The alpha significance value was determined to be 0.05.Results: Proliferation remained unchanged in the tigecycline-treated cell cultures. The gene expressions of the markers involved in anabolic pathways increased in the tigecycline-treated cell cultures. The results obtained were statistically significant (P < 0.05).Conclusion: Although tigecycline had no toxic effect on the chondrocyte cell cultures and caused no damage to the extracellular matrix, the present study was performed in an in vitro environment.

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Cite This Article

YİLMAZ, I., ATES, O., YAMAN, O., KARAARSLAN, N., KAYA, Y. E., SİRİN, D. Y., OZBEK, H. (2022). Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures. Annals of Medical Research, Cilt: 27 - Sayı: 4, 1082–1087. https://ajindex.com/articles/446443

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