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Dergiler / Annals of Medical Research / 2021 / Cilt: 28 - Sayı: 9

Effects of high dose vitamin C administration in Covid-19 patients

Umut Kara
Ender Sir
Ilker Ozdemirkan
Fatih Simsek
Sami Eksert
Serkan Senkal
Mehmet Emin Ince
Deniz Dogan
Canturk Tascı
Ahmet Cosar
Umit Savasci
Gulden Yilmaz
Ufuk Turan
Hasan Yonca
Irmak Tahmaz
Ertugrul Yazici
Sayfa
1699–1703
Yayın Tarihi
2022-10-12
DOI
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However, a significant difference was observed between the groups in terms of changes in renal function tests, and CRP values (p

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Amaç & Hipotez:Aim: There is currently no pharmacotherapy with for the treatment of COVID-19.
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Temel Bulgular & Veri:We aimed to investigate the effects of early and high-dose vitamin C (VC) therapy in hospitalized patients with COVID-19.
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Sonuç & Katkı:However, a significant difference was observed between the groups in terms of changes in renal function tests, and CRP values (p
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Aim: There is currently no pharmacotherapy with for the treatment of COVID-19. We aimed to investigate the effects of early and high-dose vitamin C (VC) therapy in hospitalized patients with COVID-19. Materials and Methods: We included patients (n=139) who received high-dose VC supplement to the standard treatment protocol into group 1 (n=58), and only those who received a standard treatment protocol into group 2 (n=81). The patients' requirement for supplemental oxygen therapy, requirement for intensive care treatment and survival rates was investigated retrospectively. Furthermore, the changes in white blood cell, C-reactive protein (CRP), procalcitonin, D-Dimer, renal function tests, ferritin, and interleukin 6 values during hospitalization were evaluated. Results: When the groups were compared in terms of clinical data, there was no significant difference in terms of the patients requiring supplemental oxygen therapy (p=0.808), requiring intensive care (p=0.662), and survival rates (p=0.185). However, a significant difference was observed between the groups in terms of changes in renal function tests, and CRP values (p

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Bu Makaleye Atıf Yap

Kara, U., Sir, E., Ozdemirkan, I., Simsek, F., Eksert, S., Senkal, S., Ince, M. E., Dogan, D., Tascı, C., Cosar, A., Savasci, U., Yilmaz, G., Turan, U., Yonca, H., Tahmaz, I., Yazici, E. (2022). Effects of high dose vitamin C administration in Covid-19 patients. Annals of Medical Research, Cilt: 28 - Sayı: 9, 1699–1703. https://ajindex.com/articles/445832

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Kaynakça (16)

  1. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020;395:1054-62
  2. Surviving Sepsis campaign. Covid19-Ssc 2020. 2020;2019
  3. Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients with 2019 Novel CoronavirusInfected Pneumonia in Wuhan, China. JAMA - J Am Med Assoc 2020;323:1061-9
  4. Carr AC. A new clinical trial to test high-dose vitamin C in patients with COVID-19. Crit Care 2020;24:1-2
  5. Fowler III AA, Kim C, Lepler L, et al. Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome. World J Crit Care Med 2017;6:85
  6. Carr AC, Rosengrave PC, Bayer S, et al. Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes. Crit Care 2017;21:1-10
  7. Bolignano D, Cernaro V, Gembillo G, et al. Antioxidant agents for delaying diabetic kidney disease progression: A systematic review and meta-analysis 2017;1-16
  8. Manuel R, Colunga L, Berrill M, et al. Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease ( COVID-19 ) 2020;11:1-11
  9. Nabzdyk CS, Bittner EA. Vitamin C in the critically ill - indications and controversies. World J Crit Care Med 2018;7:52-61
  10. Review D. New Coronavirus ( 2019-nCoV / COVID-19 ) and Vitamin C Yeni Koronavirüs ( 2019-nCoV / COVID-19 ) ve Vitamin C 2020;40:2-6
  11. Hoang BX, Shaw G, Fang W, et al. Possible application of high-dose vitamin C in the prevention and therapy of coronavirus infection. J Glob Antimicrob Resist 2020;23:256-62
  12. COVID-19 (SARS-CoV-2 Infection) Guide. Republic Of Turkey Ministry Of Health, Directorate General Of Public Health. 2020;2 Nisan 2020:25
  13. Fowler AA, Truwit JD, Hite RD, et al. Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients with Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial. JAMA - J Am Med Assoc 2019;322:1261-70
  14. Marik PE, Khangoora V, Rivera R, et al. Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective BeforeAfter Study. Chest 2017;151:1229-38
  15. Teng J, Pourmand A, Mazer-Amirshahi M. Vitamin C: The next step in sepsis management? J Crit Care 2018;43:230-4
  16. Auer BL, Auer D, Rodgers AL. Relati