KaydedilenlerDerginizi ekleyin

Dergiler / Turkish Neurosurgery / 2018 / Cilt: 28 - Sayı: 6

Neuroprotective Effects of Oleocanthal, a Compound in Virgin Olive Oil, in a Rat Model of Traumatic Brain Injury

Mesut METE
IŞIL AYDEMİR
Ülkün Ünlü ÜNSAL
Fatih ÇÖLLÜ
Gokhan VATANDAS
BEYHAN GÜRCÜ
Yusuf Kurtuluş DURANSOY
FATMA TANELİ
MEHMET İBRAHİM TUĞLU
Mehmet SELÇUKİ
Sayfa
858–865
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

This effect is achieved by reducing oxidative stress andapoptosis.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:AIM: To evaluate the neuroprotective effects of deocanthal OC in a rat model of traumatic brain injury (TBI).MATERIAL and METHODS: Twenty-six adult male, Wistar albino rats were used.
📊
Temel Bulgular & Veri:The rats were divided into 4 groups.
💡
Sonuç & Katkı:This effect is achieved by reducing oxidative stress andapoptosis.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

AIM: To evaluate the neuroprotective effects of deocanthal OC in a rat model of traumatic brain injury (TBI).MATERIAL and METHODS: Twenty-six adult male, Wistar albino rats were used. The rats were divided into 4 groups. Group 1was the sham group (n=5). Group 2 was the trauma group (n=5) where rats were treated with 10 mg/kg saline intraperitoneally (IP)twice a day. Groups 3 and 4, rats were treated with 10 (group 3, n=8) or 30 (group 4, n=8) mg/kg OC IP twice a day. For each group,brain samples were collected 72 hours after injury. Brain samples and blood were evaluated with histopathological and biochemicalmethods.RESULTS: Histopathological evaluation revealed a significant difference between Group 2 and Group 4. Biochemical findingsdemonstrated that the oxidative stress index was highest in Group 2 and lowest in Group 4.CONCLUSION: OC has a protective effect on neural cells after TBI. This effect is achieved by reducing oxidative stress andapoptosis.

🔖

Bu Makaleye Atıf Yap

METE, M., AYDEMİR, I., ÜNSAL, Ü. Ü., ÇÖLLÜ, F., VATANDAS, G., GÜRCÜ, B., DURANSOY, Y. K., TANELİ, F., TUĞLU, M. İ., SELÇUKİ, M. (2018). Neuroprotective Effects of Oleocanthal, a Compound in Virgin Olive Oil, in a Rat Model of Traumatic Brain Injury. Turkish Neurosurgery, Cilt: 28 - Sayı: 6, 858–865. https://ajindex.com/articles/417806

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (9)

  1. Abuznait AH, Qosa H, Busnena BA, El Sayed KA, Kaddoumi A: Olive-oil-derived oleocanthal enhances β-amyloid clearance as a potential neuroprotective mechanism against Alzheimer’s disease: In vitro and in vivo studies. ACS Chem Neurosci 4(6): 973-982, 2013
  2. Andrewes P, Busch JL, de Joode T, Groenewegen A, Alexandre H: Sensory properties of virgin olive oil polyphenols: Identification of deacetoxy-ligstroside aglycon as a key contributor to pungency. J Agric Food Chem 51(5):1415- 1420, 2003
  3. Beauchamp GK, Keast RS, Morel D, Lin J, Pika J, Han Q, Lee CH, Smith AB, Breslin PA: Phytochemistry: Ibuprofen-like activity in extra-virgin olive oil. Nature 437(7055):45,46, 2005 Centers for Disease Control and Prevention National Center for Injury Prevention and Control. Traumatic brain injury in the United States: A report to Congress. Available at: https:// www.cdc.gov/traumaticbraininjury/pdf/tbi_in_the_us.pdf. Accessed January 28, 2017
  4. Corona G, Spencer JP, Dessì MA: Extra virgin olive oil phenolics: Absorption, metabolism, and biological activities in the GI tract. Toxicol Ind Health 25(4-5):285-293, 2009 Dixon KJ: Pathophysiology of traumatic brain injury. Phys Med Rehabil Clin N Am 28(2):215-225, 2017 Erel O: A new automated colorimetric method for measuring total oxidant status. Clin Biochem 38:1103-1111, 2005 Erel O: A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem 37:277-285, 2004
  5. Ersoy B, Ozbilgin K, Kasirga E, Inan S, Coskun S, Tuglu I: Effect of growth hormone on small intestinal homeostasis relation to cellular mediators IGF-I and IGFBP-3. World J Gastroenterol 15(43):5418-5424, 2009
  6. Günther M, Davidsson J, Plantman S, Norgren S, Mathiesen T, Risling M: Neuroprotective effects of N-acetylcysteine amide on experimental focal penetrating brain injury in rats. J Clin Neurosci 22(9): 1477-1483, 2015
  7. Iacono A, Gómez R, Sperry J, Conde J, Bianco G, Meli R, Gómez-Reino JJ, Smith AB 3rd, Gualillo O: Effect of oleocanthal and its derivatives on inflammatory response induced by lipopolysaccharide in a murine chondrocyte cell line. Arthritis Rheum 62(6):1675-1682, 2010
  8. Kosecik M, Erel O, Sevinc E, Selek S: Increased oxidative stress in children exposed to passive smoking. Int J Cardiol 100:61-64, 2005
  9. Krohn M, Dreßler J, Bauer M, Schober K, Franke H, Ondruschka B: Immunohistochemical investigation of S100 and NSE in cases of traumatic brain injury and its application for su