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Journals / Turkish Neurosurgery / 2018 / Cilt: 28 - Sayı: 6

Neuroprotective Effects of Oleocanthal, a Compound in Virgin Olive Oil, in a Rat Model of Traumatic Brain Injury

Mesut METE
IŞIL AYDEMİR
Ülkün Ünlü ÜNSAL
Fatih ÇÖLLÜ
Gokhan VATANDAS
BEYHAN GÜRCÜ
Yusuf Kurtuluş DURANSOY
FATMA TANELİ
MEHMET İBRAHİM TUĞLU
Mehmet SELÇUKİ
Pages
858–865
DOI
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AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This effect is achieved by reducing oxidative stress andapoptosis.

📌 3 Key Takeaways

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Objective & Hypothesis:AIM: To evaluate the neuroprotective effects of deocanthal OC in a rat model of traumatic brain injury (TBI).MATERIAL and METHODS: Twenty-six adult male, Wistar albino rats were used.
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Key Findings & Data:The rats were divided into 4 groups.
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Conclusion & Impact:This effect is achieved by reducing oxidative stress andapoptosis.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

AIM: To evaluate the neuroprotective effects of deocanthal OC in a rat model of traumatic brain injury (TBI).MATERIAL and METHODS: Twenty-six adult male, Wistar albino rats were used. The rats were divided into 4 groups. Group 1was the sham group (n=5). Group 2 was the trauma group (n=5) where rats were treated with 10 mg/kg saline intraperitoneally (IP)twice a day. Groups 3 and 4, rats were treated with 10 (group 3, n=8) or 30 (group 4, n=8) mg/kg OC IP twice a day. For each group,brain samples were collected 72 hours after injury. Brain samples and blood were evaluated with histopathological and biochemicalmethods.RESULTS: Histopathological evaluation revealed a significant difference between Group 2 and Group 4. Biochemical findingsdemonstrated that the oxidative stress index was highest in Group 2 and lowest in Group 4.CONCLUSION: OC has a protective effect on neural cells after TBI. This effect is achieved by reducing oxidative stress andapoptosis.

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Cite This Article

METE, M., AYDEMİR, I., ÜNSAL, Ü. Ü., ÇÖLLÜ, F., VATANDAS, G., GÜRCÜ, B., DURANSOY, Y. K., TANELİ, F., TUĞLU, M. İ., SELÇUKİ, M. (2018). Neuroprotective Effects of Oleocanthal, a Compound in Virgin Olive Oil, in a Rat Model of Traumatic Brain Injury. Turkish Neurosurgery, Cilt: 28 - Sayı: 6, 858–865. https://ajindex.com/articles/417806

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