Dergiler / Organic Communications / 2022 / Cilt: 15 - Sayı: 2

Synthesis of new heterocycles via methylenebis(2-(2-methoxyphenyl)thiazolidin-4-one) as potential anticancer agents

Sayfa
96–107
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Almost all compounds showed activity against prostate cancer cell lines.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:NaOAc catalyzed condensation of bis(2-(2-methoxyphenyl)thiazolidin-4-one) with pmethoxybenzaldehyde in AcOH gave the corresponding chalcones.
📊
Temel Bulgular & Veri:Cyclization of the synthesized chalcones with NH2OH by refluxing in AcOH afforded the related isoxazoles fused with thiazoles.
💡
Sonuç & Katkı:Almost all compounds showed activity against prostate cancer cell lines.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

NaOAc catalyzed condensation of bis(2-(2-methoxyphenyl)thiazolidin-4-one) with pmethoxybenzaldehyde in AcOH gave the corresponding chalcones. Cyclization of the synthesized chalcones with NH2OH by refluxing in AcOH afforded the related isoxazoles fused with thiazoles. All the synthesized isoxazoles were evaluated against different tumor cell lines. Almost all compounds showed activity against prostate cancer cell lines.

🔖

Bu Makaleye Atıf Yap

SRİNİVAS, A., RAJİTHA, S. R. (2022). Synthesis of new heterocycles via methylenebis(2-(2-methoxyphenyl)thiazolidin-4-one) as potential anticancer agents. Organic Communications, Cilt: 15 - Sayı: 2, 96–107. https://ajindex.com/articles/417563

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (1)

  1. Willmore, L.J. Losigamone Dr.Willmare Schwabe. Curr. Opin. Investig. Drugs 2001, 2, 1763-1766. [2] Robert, E.; Rose, R.; Mihai, A.; Christopher, C.; Yong ping, X.; Xing, W.; John,W.; Don, K.; Andera, G.; Maya, I.; Enrique, S.; H Martin,S.; Shin sha,T. 3,4,5-Tri substituted isoxazoles as novel PPAR δ agonist. Bioorg. Med. Chem. Lett. 2006, 16, 4376-4380. [3] Basappa; Mantelingu, K.;Sadashiva, M.P.; Rangappa, K.S. A simple and efficient method for the synthesis of 1,2-benzisoxazoles:A series of its potent acetyl cholinesterase inhibitors. Ind. J. Chem. 2004, 43B, 1954-1957. [4] Mazzeri, M.; Fattori, E.S.; DOndero, R.; Ibrahim, M.; Melloni, E.; Michetti,M. N,N-Di alkyl amino substituted Chromenes and isoxazoles as potential anti-inflammatory agents. II Farmaco. 1999, 54(7), 452-460. [5] Gupta, G.; Jain, R. K.; Maikhuri, J. P.; Shukla, P. K.; Kumar, M.; Roy, A. K.; Patra, A.; Singh,V.; Batra,S. Discovery of substituted isoxazolecarbaldehydes as potent spermicides, acrosin inhibitors and mild anti-fungal agents. Human Reprod. 2005, 20, 2301-2308. [6] Suresh, G.; Venkatanath, R.; Srinivas, N; Kishore, K. Novel coumarine isoxazoline der ivatives: synthesis and study of antibacterial activities. J. Iran. Chem. Soc. 2008, 5, 67-73. [7] Rajeshwar, N.; Marcus, P.; Stetomis L.; Karlheinz, B.; Sabine, K.; Thomas, D.; Sascho, W.; Eckhard, M.; Boris, S. Curcumin-derived pyrazoles and isoxazoles: Swiss army knives or blunt tools for Alzheimer's disease. Chem. Med. Chem. 2008, 11, 165-172. [8] Zhao, H.; Liu, G.; Xin, Z.; Seby. M.D.; Pei, Z.; Szczepankiewicz, B. G.; Hazduk, P. J.; Zapa Tero, C A.; Hutchins C. W.; Lubben, T. H.; Ballaron, S. J.; Haasch, D.L.; Kaszubska,W.; Rondinone, C. M.; Trevillyan, J. M.; Jirousek, M. R. Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors. Bioorg. Med. Chem. Lett. 2004, 14, 5543-5546. [9] Hansen,J.F.; Stronge,S. Reaction of vinyl Ketoxime with N- bromo succinimide. Synthesis of isoxazoles and bromo isoxazolines. J. Heterocycl. Chem. 1977,14,1289-1289. [10] Tayade, V. B.; Jamode, V. S. A Novel method for synthesis of 3,5-diaryl Isoxazolines and 3,5-di aryl Isoxazoles. Asian J. Chem. 1997, 9, 866-868. [11] Lamberth, C. Oxazole and isoxazole chemistry in crop protection. J. Heterocycl. Chem. 2018, 55, 2035- 2045. [12] Priyanka, G.; Naresh, K.; Nudrath, U.; Madava Reddy, B.; Harinadha Babu,V. Synthesis and antitubuercular activity of isoxazole incorporated 1,2, 3-triazole derivatives. Res. J. Pharmaceut. Biol.