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AI Summary & Key Takeaways
AI Insight⚡ TL;DR(Too Long; Didn't Read)
Almost all compounds showed activity against prostate cancer cell lines.
📌 3 Key Takeaways
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Objective & Hypothesis:NaOAc catalyzed condensation of bis(2-(2-methoxyphenyl)thiazolidin-4-one) with pmethoxybenzaldehyde in AcOH gave the corresponding chalcones.
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Key Findings & Data:Cyclization of the synthesized chalcones with NH2OH by refluxing in AcOH afforded the related isoxazoles fused with thiazoles.
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Conclusion & Impact:Almost all compounds showed activity against prostate cancer cell lines.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Özet
NaOAc catalyzed condensation of bis(2-(2-methoxyphenyl)thiazolidin-4-one) with pmethoxybenzaldehyde in AcOH gave the corresponding chalcones. Cyclization of the synthesized chalcones with NH2OH by refluxing in AcOH afforded the related isoxazoles fused with thiazoles. All the synthesized isoxazoles were evaluated against different tumor cell lines. Almost all compounds showed activity against prostate cancer cell lines.
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Cite This Article
SRİNİVAS, A., RAJİTHA, S. R. (2022). Synthesis of new heterocycles via methylenebis(2-(2-methoxyphenyl)thiazolidin-4-one) as potential anticancer agents. Organic Communications, Cilt: 15 - Sayı: 2, 96–107. https://ajindex.com/articles/417563