Synthesis and anticancer (MCF-7, PC-3) activities of new 2-hydroxy-2,2-bis(4-substitutedphenyl)-N'-[(1E)-(3/4-substitutedphenyl)methylene]-acetohydrazides
All the testedcompounds showed cytotoxic activity on MCF-7 and PC-3 cell line at highest experimental concentration (100 μM).Compounds 1b (18.24 ± 7.62 μM) and 1e (7.62 ± 1.85 μM) have strong anti-proliferative activity on MCF-7 cell line,while compound 1b (45.81 ± 1.10 μM) has the strongest activity on PC-3 cell line.
📌 3 Maddede Bu Makale
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Amaç & Hipotez:A series of five –CH3, -NO2, -OCH3 and -Cl substituted 2-hydroxy-2,2-bis(4-phenyl)-N'-[(1E)-(3/4-phenyl)methylene]acetohydrazide (1a-1e) was synthesized by the reaction of 2-hydroxy-2,2-diphenylacetohydrazidewith substituted aromatic aldehydes to give intermediate Schiff bases.
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Temel Bulgular & Veri:Structures of the synthesized compounds werecharacterized using NMR (1D; 1H, 13C/APT and 2D 1H-1H COSY, and NOESY), FT-IR, UV, LC-MS/MS spectral dataand elemental analysis.
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Sonuç & Katkı:All the testedcompounds showed cytotoxic activity on MCF-7 and PC-3 cell line at highest experimental concentration (100 μM).Compounds 1b (18.24 ± 7.62 μM) and 1e (7.62 ± 1.85 μM) have strong anti-proliferative activity on MCF-7 cell line,while compound 1b (45.81 ± 1.10 μM) has the strongest activity on PC-3 cell line.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri
Abstract
A series of five –CH3, -NO2, -OCH3 and -Cl substituted 2-hydroxy-2,2-bis(4-phenyl)-N'-[(1E)-(3/4-phenyl)methylene]acetohydrazide (1a-1e) was synthesized by the reaction of 2-hydroxy-2,2-diphenylacetohydrazidewith substituted aromatic aldehydes to give intermediate Schiff bases. Structures of the synthesized compounds werecharacterized using NMR (1D; 1H, 13C/APT and 2D 1H-1H COSY, and NOESY), FT-IR, UV, LC-MS/MS spectral dataand elemental analysis. The geometry of compounds 1a-1e were determined to be “E” by NOESY. All the testedcompounds showed cytotoxic activity on MCF-7 and PC-3 cell line at highest experimental concentration (100 μM).Compounds 1b (18.24 ± 7.62 μM) and 1e (7.62 ± 1.85 μM) have strong anti-proliferative activity on MCF-7 cell line,while compound 1b (45.81 ± 1.10 μM) has the strongest activity on PC-3 cell line.
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Bu Makaleye Atıf Yap
REİS, R., SİPAHİ, H., SELLİTEPE, H. E., DOĞAN, İ. S., KAYIKÇI, N., YAYLI, N. (2022). Synthesis and anticancer (MCF-7, PC-3) activities of new 2-hydroxy-2,2-bis(4-substitutedphenyl)-N'-[(1E)-(3/4-substitutedphenyl)methylene]-acetohydrazides. Organic Communications, Cilt: 11 - Sayı: 3, 142–148. https://ajindex.com/articles/653539
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