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Dergiler / Turkish Journal of Hematology / 2002 / Cilt: 19 - Sayı: 1

Tumour necrosis factor-alpha gene polymorphism (-308 G-A) in Turkish pediatric thrombosis patients

Nejat AKAR
Metis HASİPEK
Sayfa
39–41
DOI
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We aimed to study this polymorphic site in Turkish children with the diagnosis of thrombosis.

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Amaç & Hipotez:Tumour necrosis factor-alpha (TNF-alpha) plays an important role in clot formation by activating platelets, monocytes and endothelial cells and inducing procoagulant substances such as negatively charged phospolipids or tissue factor.
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Temel Bulgular & Veri:There is a genetically controlled inter-individual variation of TNF-alpha production.Carrying TNF2 allele could have a slight protective effect against the occurence of stroke in Sickle Cell Disease patients.
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Sonuç & Katkı:We aimed to study this polymorphic site in Turkish children with the diagnosis of thrombosis.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Tümör nekroz faktör · Genotip · Tromboz

Özet

Tumour necrosis factor-alpha (TNF-alpha) plays an important role in clot formation by activating platelets, monocytes and endothelial cells and inducing procoagulant substances such as negatively charged phospolipids or tissue factor. There is a genetically controlled inter-individual variation of TNF-alpha production.Carrying TNF2 allele could have a slight protective effect against the occurence of stroke in Sickle Cell Disease patients. We aimed to study this polymorphic site in Turkish children with the diagnosis of thrombosis.

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Bu Makaleye Atıf Yap

AKAR, N., HASİPEK, M. (2002). Tumour necrosis factor-alpha gene polymorphism (-308 G-A) in Turkish pediatric thrombosis patients. Turkish Journal of Hematology, Cilt: 19 - Sayı: 1, 39–41. https://ajindex.com/articles/412984

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  1. Wilson A, Symons I, Mc Dowell T, Mc Devitt H. Ef-fects of a polymorphism of the human tumour nec-rosis factor-alpha promoter on transcriptional acti-vation. Proc Nati Acad Sci 1997;94:3195-9. 2.Brown K, Luddington R, Baglin T. A common poly-morphism in the tumour necrosis factor-alpha geneassociated with high TNF levels is not a risk factorfor venous thromboembolism. Br J Haematol1998;101:480-2. 3.Bertolaccini ML, Atsumi T, Lanchbury JS, Caliz AR,Katsumata K, Vaughan RW, Kondeatis E, Kha-mashta MA, Koike T, Hughes GRV. Plasma TumorNecrosis Factor-a levels and th -238 A promoterpolymorphism in Patients with AntiphospolipidSyndrome. Thromb Haemost 2001;85:198-203. 4.Carroll JE, McKie V, Kutlar A. Are Sickle cell dise-ase patients with stroke genetically predisposed tothe event by inheriting a tendency to high TumorNecrosis Factor levels? Am J Hematol 1998;58:250. 5.Akar N, Akar E, Yýlmaz E, Deda G. PlasminogenActivator Inhibitor-1 4G/5G Polymorphism in Tur-kish Children with cerebral infarct and effect onFactor V 1691 A mutation. J Child Neurology2001;16: 294. 6.Akar N, Duman T, Akar E, Deda G, Sipahi T. The a2gene alleles of the platelet collagen reseptor intein a2ß1 in Turkish children with cerebral infarct.Thrombosis Research 2001;102:121-3. 7.Akar N, Akar E, Dalgýn G, Sözüöz A, Ömürlü K, CinÞ. Frequency of factor V 1691 GA mutation in Tur-kish population. Thromb Haemostatis 1997;78:1527-8.