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Journals / Turkish Journal of Hematology / 2002 / Cilt: 19 - Sayı: 1

Tumour necrosis factor-alpha gene polymorphism (-308 G-A) in Turkish pediatric thrombosis patients

Nejat AKAR
Metis HASİPEK
Pages
39–41
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We aimed to study this polymorphic site in Turkish children with the diagnosis of thrombosis.

📌 3 Key Takeaways

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Objective & Hypothesis:Tumour necrosis factor-alpha (TNF-alpha) plays an important role in clot formation by activating platelets, monocytes and endothelial cells and inducing procoagulant substances such as negatively charged phospolipids or tissue factor.
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Key Findings & Data:There is a genetically controlled inter-individual variation of TNF-alpha production.Carrying TNF2 allele could have a slight protective effect against the occurence of stroke in Sickle Cell Disease patients.
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Conclusion & Impact:We aimed to study this polymorphic site in Turkish children with the diagnosis of thrombosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Tümör nekroz faktör · Genotip · Tromboz

Özet

Tumour necrosis factor-alpha (TNF-alpha) plays an important role in clot formation by activating platelets, monocytes and endothelial cells and inducing procoagulant substances such as negatively charged phospolipids or tissue factor. There is a genetically controlled inter-individual variation of TNF-alpha production.Carrying TNF2 allele could have a slight protective effect against the occurence of stroke in Sickle Cell Disease patients. We aimed to study this polymorphic site in Turkish children with the diagnosis of thrombosis.

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Cite This Article

AKAR, N., HASİPEK, M. (2002). Tumour necrosis factor-alpha gene polymorphism (-308 G-A) in Turkish pediatric thrombosis patients. Turkish Journal of Hematology, Cilt: 19 - Sayı: 1, 39–41. https://ajindex.com/articles/412984

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References (1)

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