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Dergiler / Records of Natural Products / 2017 / Cilt: 11 - Sayı: 6

Phytochemical and Biological Investigations on Cephalaria anatolica

Gaye SUMER
Nazlı Böke SARIKAHYA
Süheyla KIRMIZIGÜL
Sayfa
497–528
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

None of the compounds changed IL-2 levels significantly and showed hemolytic activity

📌 3 Maddede Bu Makale

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Amaç & Hipotez:The aerial parts of Cephalaria anatolica yielded two previously undescribed hederagenin-type triterpene glycosides, namely cephosides B (1) and C (2), in addition to eleven known natural compounds.
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Temel Bulgular & Veri:The new compounds were identified as 3-O-β-D-glucopyranosyl-(1  3)--D-glucopyranosyl-(1  3)-α-Lrhamnopyranosyl-(1 glucopyranosyl ester (1) and 3-O-α-L-rhamnopyranosyl-(1  4)--D-glucopyranosyl-( 1  3)-α-Lrhamnopyranosyl-(1 glucopyranosyl ester (2) by 1D and 2D NMR spectroscopic data, HRESIMS analysis and chemical evidence.
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Sonuç & Katkı:None of the compounds changed IL-2 levels significantly and showed hemolytic activity
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

The aerial parts of Cephalaria anatolica yielded two previously undescribed hederagenin-type triterpene glycosides, namely cephosides B (1) and C (2), in addition to eleven known natural compounds. The new compounds were identified as 3-O-β-D-glucopyranosyl-(1  3)--D-glucopyranosyl-(1  3)-α-Lrhamnopyranosyl-(1 glucopyranosyl ester (1) and 3-O-α-L-rhamnopyranosyl-(1  4)--D-glucopyranosyl-( 1  3)-α-Lrhamnopyranosyl-(1 glucopyranosyl ester (2) by 1D and 2D NMR spectroscopic data, HRESIMS analysis and chemical evidence. The two new triterpenoid saponins and the n-butanol extract were evaluated for their hemolytic activity in human erythrocyte cells and immunomodulatory properties in activated whole blood cells by PMA plus ionomycin.While only n-butanol extract increased IL-1β concentration strongly with a value of 760.52 pg/mL, cephoside C and n-butanol extract augmented a slight IFN-γ secretion with values of 4874.11 and 4750.20 pg/mL, respectively. None of the compounds changed IL-2 levels significantly and showed hemolytic activity

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Bu Makaleye Atıf Yap

SUMER, G., SARIKAHYA, N. B., KIRMIZIGÜL, S. (2017). Phytochemical and Biological Investigations on Cephalaria anatolica. Records of Natural Products, Cilt: 11 - Sayı: 6, 497–528. https://ajindex.com/articles/308601

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