Dergiler / Records of Natural Products / 2021 / Cilt: 15 - Sayı: 6

Saponins from Twenty-Two Cephalaria Species

Sayfa
537–546
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Therefore, due to the different activities and usages of the identified compounds, these findings may find application in a number of industries such as nutraceutical, pharmaceutical, medical and cosmetic industries.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Saponins in the Cephalaria species have a broad spectrum of biological properties and application potentials.
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Temel Bulgular & Veri:This research aimed to develop a novel method to tentatively identify and quantify triterpenes and saponins in 22 Cephalaria species by LC-HR/MS method.
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Sonuç & Katkı:Therefore, due to the different activities and usages of the identified compounds, these findings may find application in a number of industries such as nutraceutical, pharmaceutical, medical and cosmetic industries.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Saponins in the Cephalaria species have a broad spectrum of biological properties and application potentials. This research aimed to develop a novel method to tentatively identify and quantify triterpenes and saponins in 22 Cephalaria species by LC-HR/MS method. In this study, we provided a broad screening of important biologically active triterpenes and saponins with high separation ability, high sensitivity and high selectivity. This is the first report to prove that Cephalaria species can be a good source of tormentic acid which has many biological activities in literature. The main triterpene compound, tormentic acid was presented at the level between 74.02 mg/kg and 75702.0 mg/kg in n-butanol extract of Cephalaria species. The source of some biologically active saponins such as davisianoside B, aristatoside C, elmalienoside A, balansoide B and scoposide B were also determined with this study, for the first time. Therefore, due to the different activities and usages of the identified compounds, these findings may find application in a number of industries such as nutraceutical, pharmaceutical, medical and cosmetic industries.

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Bu Makaleye Atıf Yap

SARİKAHYA, N. B., GOREN, A. C., OKKALİ, G. S., KİRMİZİGUL, S. (2021). Saponins from Twenty-Two Cephalaria Species. Records of Natural Products, Cilt: 15 - Sayı: 6, 537–546. https://ajindex.com/articles/340361

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Kaynakça (1)

  1. 1] M. Guclu-Ustundag and G. Mazza (2007). Saponins: properties, applications and processing, Crit. Rev. Food Sci. Nutr. 47, 231-258. [2] I. Podolak, A. Galanty and D. Sobolewska (2010). Saponins as cytotoxic agents: a review, Phytochem Rev. 9, 425-474. [3] S.G. Sparg, M.E. Light and J. Van Staden (2004). Biological activities and distribution of plant saponins, J. Ethnopharmacol. 94, 219-243. [4] M.A. Lacaille-Dubois and H. Wagner (1996). A review of the biological and pharmacological activities of saponins, Phytomedicine 2, 363-386. [5] A. Nalbantsoy, T. Nesil, S. Erden, I. Calis and E. Bedir (2011). Adjuvant effects of Astragalus saponins macrophyllosaponin B and astragaloside VII, J. Ethnopharmacol. 134, 897-903. [6] G. Ragupathi, J.R. Gardner, P.O. Livingston and D.Y. Gin (2011). Natural and synthetic saponin adjuvant QS-21 for vaccines against cancer, Expert Rev. Vaccines 10(4), 463-470. [7] N. Yakubogullari, R. Genc, F. Coven, A. Nalbantsoy and E. Bedir (2019). Development of adjuvant nanocarrier systems for seasonal influenza A (H3N2) vaccine based on Astragaloside VII and gum tragacanth, Vaccine 37(28), 3638-3645. [8] N.B. Sarikahya and S. Kirmizigul (2010). Antimicrobial triterpenoid glycosides from Cephalaria scoparia, J. Nat. Prod. 73, 825-830. [9] K. Mustafayeva, C.D. Giorgio, R. Elias, Y. Kerimov, E. Ollivier and M. De Meo (2010). DNA-Damaging, mutagenic, and clastogenic activities of gentiopicroside isolated from Cephalaria kotschyi roots, J. Nat. Prod. 73, 99-103. [10] N. Tabatadze, R. Elias, R. Faure, P. Gerkens, M.C. De Pauw-Gillet, E. Kemertelidze, A. Chea and E. Ollivier (2007). Cytotoxic triterpenoid saponins from the roots of Cephalaria gigantea, Chem. Pharm. Bull. 55, 102- 105. [11] S. Pasi, N. Aligiannis, H. Pratsinis, A.L. Skaltsounis and I.B. Chinou (2009). Biologically active triterpenoids from Cephalaria ambrosioide, Planta Med. 75, 163-167. [12] D. Godjevac, V. Vajs, N. Menkovic, V. Tesevic, P. Janackovic and S. Milosavljevic (2004). Flavonoids from flowers of Cephalaria pastricensis and their antiradical activity, J. Serbian Chem. Soc. 69, 883-886. [13] P.H. Davis. (1972). Flora of Turkey and the east Aegean Islands, Edinburgh: University of Edinburgh Press; 4, 585-592. [14] R.S. Gokturk and H. Sumbul (2014). A taxonomic revision of the genus Cephalaria (Caprifoliaceae) in Turkey, Turk. J. Botan. 38, 927-968. [15] H. Top, N.B. Sarikahya, A. Nalbantsoy and S. Kirmizigul (2017). Immunomodulatory, hemolytic properties and cytotoxi