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Dergiler / Organic Communications / 2020 / Cilt: 13 - Sayı: 4

Synthesis, spectral characterization, antimicrobial activity and docking studies against DNA Gyrase-A of new 4-chloro-3- nitrobenzene sulfonamide derivatives

K. Pushpa KUMAR
Reddi Mohan Naidu KALLA
Mavallur VARALAKSHMI
Chintha VENKATARAMAİAH
K. Swetha KUMARİ
Jayakumar KANNALİ
D. Venkatramana REDDY
Chamarthi NAGARAJU
Sayfa
155–164
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Most of the compounds showed good to moderate antimicrobial activities and binding affinity towards DNA Gyrase-A structure

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Amaç & Hipotez:A series of new 4-chloro-3-nitrobenzene sulfonamide derivatives 3(a-j) were synthesized from 4-chloro-3- nitrobenzene sulfonyl chloride by reacting various amino acid esters and amines 2(a-j) in high yields.
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Temel Bulgular & Veri:The structures of all the synthesized compounds were characterized by the IR, NMR (1H & 13C), mass and elemental analyses.
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Sonuç & Katkı:Most of the compounds showed good to moderate antimicrobial activities and binding affinity towards DNA Gyrase-A structure
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

A series of new 4-chloro-3-nitrobenzene sulfonamide derivatives 3(a-j) were synthesized from 4-chloro-3- nitrobenzene sulfonyl chloride by reacting various amino acid esters and amines 2(a-j) in high yields. The structures of all the synthesized compounds were characterized by the IR, NMR (1H & 13C), mass and elemental analyses. Further, all the synthesized compounds were tested for the antimicrobial activity and docking studies were carried out with DNA Gyrase-A. Most of the compounds showed good to moderate antimicrobial activities and binding affinity towards DNA Gyrase-A structure

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Bu Makaleye Atıf Yap

KUMAR, K. P., KALLA, R. M. N., VARALAKSHMI, M., VENKATARAMAİAH, C., KUMARİ, K. S., KANNALİ, J., REDDY, D. V., NAGARAJU, C. (2020). Synthesis, spectral characterization, antimicrobial activity and docking studies against DNA Gyrase-A of new 4-chloro-3- nitrobenzene sulfonamide derivatives. Organic Communications, Cilt: 13 - Sayı: 4, 155–164. https://ajindex.com/articles/288460

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Kaynakça (13)

  1. Gokcen, T.; Al, M.; Topal, M.; Gulcin, I.; Ozturk, T.; Goren, A.C. Synthesis of some natural sulphonamide derivatives as carbonic anhydrase inhibitors. Org. Commun. 2017, 10, 15-23
  2. Benedetti, P.G.D. Advances in drug research. Volume 16. Edited by: Testa B. Academic Press. London and New York; 1987:227
  3. Mengelers, M. J.; Hougee, P. E.; Jansson, L. H.; Van Miert, A.S. Structure-activity relationship between antibacterial activities and physicochemical properties of sulfonamides. J. Vet. Pharmacol. Therap. 1997, 20, 276–283
  4. Akçam, F. Z.; Karaslan, D.; Doğan, M.; Yaylı, G. Microbiological surveillance in the Intensive Care Unit: A tertiary hospital experience. Med. Sci. Monit. 2006, 12, 81-85
  5. Monika G.; Mohan, C. Development of drugs based on imidazole and benzimidazole bioactive heterocycles: recent advances and future directions. Med. Chem. Res. 2016, 25, 173-210
  6. Gumus, M.; Sert, Y.; Koca, I. Synthesis, characterization and theoretical studies of novel sulfonamidealdehydes derivatives having tautomeric forms. Org. Commun. 2019, 12, 176-187
  7. Yotphan, S.; Sumunnee, L.; Beukeaw, D.; Buathongjan, C.; Reutrakul, V. Iodine-catalyzed expeditious synthesis of sulfonamides from sulfonyl hydrazides and amines. Org. Biomol. Chem. 2016, 14, 590-597
  8. Tan, G. T.; Wickramasingle, A.; Verma, S.; Singh, R.; Hughes, S. H.; Pezzuto, J. M.; Baba, M.; Mohan, P. Potential anti-AIDS naphthalenesulfonic acid derivatives. synthesis and inhibition of HIV-1 induced cytopathogenesis and HIV-1 and HIV-2 reverse transcriptase activities. J. Med. Chem. 1992, 35, 4846-4853
  9. Mohan, P.; Singh, R.; Baba, M. Potential anti-AIDS agents. Synthesis and antiviral activity of naphthalenesulfonic acid derivatives against HIV-1 and HIV-2. J. Med. Chem. 1991, 34, 212–217
  10. Boriack, P. A.; Christianson, D.W.; Kingery-Wood, J.; Whitesides, G.M. Secondary Interactions Significantly Removed from the Sulfonamide Binding Pocket of Carbonic Anhydrase II Influence Inhibitor Binding Constants. J. Med. Chem. 1995, 38, 2286-2291
  11. Leppik, I. E. Antiepileptic Drugs in Development: Prospects for the Near Future. Epilepsia 1994, 35, S29-S40
  12. Tanimukai, H.; lnui, M,; Hariguchi, S.; Kaneko, Z. Antiepileptic property of inhibitors of carbonic anhydrase. Biochem. Pharmacol. 1995, 14, 961-970
  13. Flaherty, P. T.; Greenwood, T. D.; Manheim, A. L.; Wolfe, J. F. Synthesis and evaluation of N- (phenylacetyl)trifluoromethanesulfonamides as anticonvulsant agents. J. Med.