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AI Summary & Key Takeaways
AI Insight⚡ TL;DR(Too Long; Didn't Read)
Most of the compounds showed good to moderate antimicrobial activities and binding affinity towards DNA Gyrase-A structure
📌 3 Key Takeaways
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Objective & Hypothesis:A series of new 4-chloro-3-nitrobenzene sulfonamide derivatives 3(a-j) were synthesized from 4-chloro-3- nitrobenzene sulfonyl chloride by reacting various amino acid esters and amines 2(a-j) in high yields.
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Key Findings & Data:The structures of all the synthesized compounds were characterized by the IR, NMR (1H & 13C), mass and elemental analyses.
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Conclusion & Impact:Most of the compounds showed good to moderate antimicrobial activities and binding affinity towards DNA Gyrase-A structure
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Özet
A series of new 4-chloro-3-nitrobenzene sulfonamide derivatives 3(a-j) were synthesized from 4-chloro-3- nitrobenzene sulfonyl chloride by reacting various amino acid esters and amines 2(a-j) in high yields. The structures of all the synthesized compounds were characterized by the IR, NMR (1H & 13C), mass and elemental analyses. Further, all the synthesized compounds were tested for the antimicrobial activity and docking studies were carried out with DNA Gyrase-A. Most of the compounds showed good to moderate antimicrobial activities and binding affinity towards DNA Gyrase-A structure
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Cite This Article
KUMAR, K. P., KALLA, R. M. N., VARALAKSHMI, M., VENKATARAMAİAH, C., KUMARİ, K. S., KANNALİ, J., REDDY, D. V., NAGARAJU, C. (2020). Synthesis, spectral characterization, antimicrobial activity and docking studies against DNA Gyrase-A of new 4-chloro-3- nitrobenzene sulfonamide derivatives. Organic Communications, Cilt: 13 - Sayı: 4, 155–164. https://ajindex.com/articles/288460