The present method provides significant advantages of organo-catalyst such as inexpensive, highly stable, environmentally benign and commercially available as well as solvent free reaction conditions and high conversions of the products with excellent yield.
📌 3 Maddede Bu Makale
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Amaç & Hipotez:A simple, efficient and eco-friendly general protocol has been developed for the synthesis of three-component reaction methodology of Strecker’s α-amino nitriles by using various aldehyde or ketone, amines and trimethylsilyl cyanide (TMS-CN).
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Temel Bulgular & Veri:This method was carried out under solvent free condition at room temperature for preparation of variety of α-amino nitriles derivatives in excellent yields.
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Sonuç & Katkı:The present method provides significant advantages of organo-catalyst such as inexpensive, highly stable, environmentally benign and commercially available as well as solvent free reaction conditions and high conversions of the products with excellent yield.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri
Özet
A simple, efficient and eco-friendly general protocol has been developed for the synthesis of three-component reaction methodology of Strecker’s α-amino nitriles by using various aldehyde or ketone, amines and trimethylsilyl cyanide (TMS-CN). In this methodology, succinic acid is used as a novel and efficient organo-catalyst in catalytic amount. This method was carried out under solvent free condition at room temperature for preparation of variety of α-amino nitriles derivatives in excellent yields. The present method provides significant advantages of organo-catalyst such as inexpensive, highly stable, environmentally benign and commercially available as well as solvent free reaction conditions and high conversions of the products with excellent yield.
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Bu Makaleye Atıf Yap
GHOGARE, R. S. (2020). Succinicacid: anovel and efficient organo-catalyst for synthesis of α-amino nitriles under solvent free condition. Organic Communications, Cilt: 13 - Sayı: 3, 103–113. https://ajindex.com/articles/288450
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