The results show that all the synthesized compounds displayed significant activity against S. epidermis, M. luteus, B. cereus, B. abortus and C. albicans when compared to standard drugs.
📌 3 Maddede Bu Makale
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Amaç & Hipotez:A series of novel substituted isoxazolidine derivatives were synthesized by 1,3-dipolar cycloaddition reaction.
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Temel Bulgular & Veri:The structures of the synthesized compounds were characterized using spectroscopic methods.
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Sonuç & Katkı:The results show that all the synthesized compounds displayed significant activity against S. epidermis, M. luteus, B. cereus, B. abortus and C. albicans when compared to standard drugs.
A series of novel substituted isoxazolidine derivatives were synthesized by 1,3-dipolar cycloaddition reaction. The structures of the synthesized compounds were characterized using spectroscopic methods. All the synthesized compounds were screened for their antibacterial activities against Gram-positive and Gram-negative bacteria and for their antifungal activities against a yeast strain. The results show that all the synthesized compounds displayed significant activity against S. epidermis, M. luteus, B. cereus, B. abortus and C. albicans when compared to standard drugs.
YANMAZ, V., DISLI, A., YAVUZ, S., OGUTCU, H., DILEK, G. (2019). Synthesis of Some Novel Isoxazolidine Derivatives via 1,3-Dipolar Cycloaddition and Their Biological Evaluation. Gazi University Journal of Science, Cilt: 32 - Sayı: 1, 78–89. https://ajindex.com/articles/254482
Zhu, J., Lines B.M., Ganton, M.D., Kerr, M.A. and Workentin, M.S., “Efficient synthesis of isoxazolidine tethered monolayer-protected gold nanoparticles (MPGNs) via 1,3-dipolar cycloadditions under high-pressure conditions”, J. Org. Chem., 73(3): 1099-1105, (2008).
Karthikeyan, K., Perumal, P.T., Etti, S. and Shanmugam, G., “Diastereoselective syntheses of pyrazolyl via 1,3-dipolar cycloaddition”, Tetrahedron, 63(43): 10581-10586, (2007).
Dondas, H.A., Cummins, J.E., Grigg, R. and Thornton, P.M., “X=Y–ZH Systems as potential 1,3-dipoles. Part 53: Sequential nucleophilic ring opening-1,3-dipolar cycloaddition reactions of Z-oxime anions with aziridines and dipolarophiles”, Tetrahedron, 57(37): 7951-7964, (2001).
Casuscelli, F., Chiaccho, U., Rescifina, A., Romeo, R., Romeo, G., Tommasini, S. and Uccella, N., “Ring-opening of isoxazolidine nucleus: Competitive formation of α,β-enones and tetrahydro-1,3-oxazines”, Tetrahedron, 51(10): 2979-2990, (1995).
Damodiran, M., Sivakumar, P.M., Senthil Kumar, R., Muralidharan, D., Kumar, B.V.N.P., Doble, M. and Perumal, P.T., “Antibacterial activity, quantitative structure–activity relationship and diastereoselective synthesis of ısoxazolidine derivatives via 1,3-dipolar cycloaddition of D-glucose derived nitrone with olefin”, Chem. Biol. Drug. Des., 74(5): 494-506, (2009).
Yin, Z., Zhang, J., Wu, J., Liu, C., Sioson, K., Devany, M., Hu, C. and Zheng, S., “Double hetero-Michael addition of N substituted hydroxylamines to quinone monoketals: synthesis of bridged isoxazolidines”, Org. Lett.,15(4): 3534-3537, (2013).
Ali, A.S., Khan, J.H. and Wazeer, M.I.M., “The regiochemistry and stereochemistry of 1,3-dipolar cycloaddition of cyclic nitrones”, Tetrahedron, 44(18): 5911-5920, (1998). Jäger, V. and Müller, I., “Synthesis of amino sugars via isoxazolines: Nitrile oxide-furan adducts as key intermediates in the isoxazoline route towards novel amino sugar derivatives”, Tetrahedron, 41(17): 3519-3528, (1985).
Merino, P., Franco, S., Merchan, F.L. and Tejero, T., “Asymmetric synthesis of an isoxazolidine nucleoside analog of thymine polyoxin C”, Tetrahedron Lett., 39(35): 6411-6414, (1988).
Nora, G.P., Miller, M.J. and Möllmann, U., “The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels–Alder adducts”, Bioorg. Med. Chem. Lett., 16(15): 3966-3970, (2006).
Litvinovskaya, R.P., Koval, N.V. and Khripach, V.A., “Synthesis of modified vitamin D precursors”, Chem. Hetero. Comp., 36(2): 1