Yöntem: Çalışmaya orta-ağır OUAS apne-hipopne indeksi >15 tanısı konan 15 hasta ile kontrol grubu oluşturulmak üzere polisomnografi tetkiki normal sonuçlanan apne-hipopne indeksi
📌 3 Maddede Bu Makale
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Amaç & Hipotez:Amaç: Bu çalışmada obstrüktif uyku apne sendromu OUAS olan hastalarda mide-duodenum epitelyal hücre hasarı varlığı araştırılmıştır.
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Temel Bulgular & Veri:Amaç: Bu çalışmada obstrüktif uyku apne sendromu OUAS olan hastalarda mide-duodenum epitelyal hücre hasarı varlığı araştırılmıştır.
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Sonuç & Katkı:Yöntem: Çalışmaya orta-ağır OUAS apne-hipopne indeksi >15 tanısı konan 15 hasta ile kontrol grubu oluşturulmak üzere polisomnografi tetkiki normal sonuçlanan apne-hipopne indeksi
Amaç: Bu çalışmada obstrüktif uyku apne sendromu OUAS olan hastalarda mide-duodenum epitelyal hücre hasarı varlığı araştırılmıştır. Yöntem: Çalışmaya orta-ağır OUAS apne-hipopne indeksi >15 tanısı konan 15 hasta ile kontrol grubu oluşturulmak üzere polisomnografi tetkiki normal sonuçlanan apne-hipopne indeksi
Abstract
Aim: The aim of this study was to investigate the gastroduodenal epitelial cell damage in patients with moderate to severe obstructive sleep apnea syndrome. Material and method: Fifteen patient apnea-hipopnea index >15 and 15 control apnea-hipopnea index
Valle JD. Peptic ulcer disease and related disorders. In: Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J, eds. Harrison’s principles of internal medicine (17th edition). New York: McGraw- Hill; 2008:1855-1872.
Newton EB, Versland MR, Sepe TE. Giant duodenal ulcers. World J Gastroenterol 2008;14:4995-4999.
Aro P, Storskrubb T, Ronkainen J, Bolling-Sternevald E, Engstrand L, Vieth M, Stolte M, Talley NJ, Agréus L. Peptic ulcer disease in a general adult population: the Kalixanda study: a random population-based study. Am J Epidemiol 2006;163:1025-1034.
Calam J, Baron JH. ABC of the upper gastrointestinal tract: pathophysiology of duodenal and gastric ulcer and gastric cancer. BMJ 2001;323:980-982.
Whittle BJ, Lopez-Belmonte J. Actions and interac- tions of endothelins, prostacyclin and nitric oxide in the gastric mucosa. J Physiol Pharmacol 1993;44:91-107.
Whittle BJ, Lopez-Belmonte J. Interactions between the vascular peptide endothelin-1 and sensory neu- ropeptides in gastric mucosal injury. Br J Pharmacol 1991;102:950-954.
Iaquinto G, Giardullo N, Taccone W, Leandro G, Pasquale L, De Luca L, Szabo S. Role of endogenous endothelin-1 in ethanol-induced gastric mucosal damage in humans. Dig Dis Sci 2003;48:663-669.
Tandon R, Khanna HD, Dorababu M, Goel RK. Oxidative stress and antioxidants status in peptic ul- cer and gastric carcinoma. Indian J Physiol Pharmacol 2004;48:115-118.
Schwartz AR, Patil SP, Laff an AM, Polotsky V, Schneider H, Smith PL. Obesity and obstructive sleep apnea. pathogenic mechanisms and therapeutic app- roaches. Proc Am Thorac Soc 2008;5:185-192. White DP. Sleep apnea. Proc Am Thorac Soc 2006;3:124–128.
Sanner BM, Konermann M, Sturm A, Müller HJ, Zidek W. Right ventricular dysfunction in patients with obstructive sleep apnoea syndrome. Eur Respir J 1997;10:2079-2083.
Pillar G, Shehadeh N. Abdominal fat and sle- ep apnea: the chicken or the egg? Diabetes Care 2008;31:303-309. p MS, Tse HF, Lam B, Tsang KW, Lam WK. Endothelial function in obstructive sleep apnea and response to treatment. Am J Respir Crit Care Med 2004; 169: 348-353.
Nieto FJ, Herrington DM, Redline S, Benjamin EJ, Robbins JA. Sleep apnea and markers of vascular endothelial function in a large community sample of older adults. Am J Respir Crit Care Me