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Dergiler / Türk Spor ve Egzersiz Dergisi / 2019 / Cilt: 21 - Sayı: 1

A Study on Effect of Melatonin in Dyslipidemia Caused by Experimentally Diabetes

Deniz ULUIŞIK
Ercan KESKİN
Durmuş HATİPOĞLU
Sayfa
117–121
Yayın Tarihi
2019-04-30
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

It was concluded that the administration of melatonin to streptozotocin-induced diabetic rats may have positive effects on lipid profile.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:In this study, it was aimed to determine the effects of melatonin application on lipid profile in streptozotocin-induced diabetic rats.
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Temel Bulgular & Veri:Melatonin group animals received 50 mg/kg melatonin intraperitoneally in daily for eight weeks.
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Sonuç & Katkı:It was concluded that the administration of melatonin to streptozotocin-induced diabetic rats may have positive effects on lipid profile.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Diabetes · melatonin · TNF-α

Abstract

In this study, it was aimed to determine the effects of melatonin application on lipid profile in streptozotocin-induced diabetic rats. Animals in control group were not any treatment. Melatonin group animals received 50 mg/kg melatonin intraperitoneally in daily for eight weeks. Diabetes was induced by subcutaneous injections of streptozotocin at dose of 40 mg/kg for two days as a single dose per day in diabetes group animals. Animals in Diabetes+Melatonin group were made diabetic by streptozotocin in the same way and then these animals received 50 mg/kg melatonin intraperitoneally in daily for eight weeks. In blood samples taken from all animals, TNF-α, triglyceride, total cholesterol, LDL and HDL were determined. In diabetes group, TNF-α level were high (p<0.05). The changes in TNF-α level with melatonin application to diabetic rats were important (p<0.05). In diabetic rats, triglyceride and LDL levels were found to be enhanced compared to control group (p<0.05), HDL level was significantly low (p<0.05), while the change in total cholesterol level was not important. With the melatonin application to diabetic rats, HDL level was found to be higher (p<0.05) and LDL level was lower than diabetes group (p<0.05). It was concluded that the administration of melatonin to streptozotocin-induced diabetic rats may have positive effects on lipid profile.

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Bu Makaleye Atıf Yap

ULUIŞIK, D., KESKİN, E., HATİPOĞLU, D. (2019). A Study on Effect of Melatonin in Dyslipidemia Caused by Experimentally Diabetes. Türk Spor ve Egzersiz Dergisi, Cilt: 21 - Sayı: 1, 117–121. https://ajindex.com/articles/205629

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