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Dergiler / Turkish Journal of Chemistry / 2004 / Cilt: 28 - Sayı: 3

Chemically Crosslinked N-Vinyl-2-Pyrrolidone/2-Hydroxyethyl Methacrylate (VP/HEMA) Copolymer for the Controlled Release of Cyclic Oligopeptide

Bashir AHMAD
Shumaila BASHIR
Shams-un NISA
M. B. HUGLIN
Sayfa
279–286
Yayın Tarihi
2004-03-01
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Hydrophilicity, hydrophobicity and monomer composition in the copolymer controlled the drug release from the hydrogels.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Crosslinked copolymers of various compositions of N-vinyl-2-pyrrolidone (VP) and 2-hydroxyethyl methacrylate (HEMA) were prepared chemically in the presence of a crosslinking agent.
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Temel Bulgular & Veri:The swelling mechanism was non-Fickian with about 86% conversion of feed composition to crosslinked copolymer.
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Sonuç & Katkı:Hydrophilicity, hydrophobicity and monomer composition in the copolymer controlled the drug release from the hydrogels.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:N-vinyl-2-pyrrolidone · 2-hydroxyethyl methacrylate · Hydrogels

Özet

Crosslinked copolymers of various compositions of N-vinyl-2-pyrrolidone (VP) and 2-hydroxyethyl methacrylate (HEMA) were prepared chemically in the presence of a crosslinking agent. The swelling mechanism was non-Fickian with about 86% conversion of feed composition to crosslinked copolymer. The reactivity ratios r1 = 0.045 and r2 = 3.07 for VP and HEMA indicate that HEMA is more reactive than VP in the reaction. Hydrophilicity, hydrophobicity and monomer composition in the copolymer controlled the drug release from the hydrogels.

Abstract

Crosslinked copolymers of various compositions of N-vinyl-2-pyrrolidone (VP) and 2-hydroxyethyl methacrylate (HEMA) were prepared chemically in the presence of a crosslinking agent. The swelling mechanism was non-Fickian with about 86% conversion of feed composition to crosslinked copolymer. The reactivity ratios r1 = 0.045 and r2 = 3.07 for VP and HEMA indicate that HEMA is more reactive than VP in the reaction. Hydrophilicity, hydrophobicity and monomer composition in the copolymer controlled the drug release from the hydrogels.

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Bu Makaleye Atıf Yap

AHMAD, B., BASHIR, S., NISA, S., HUGLIN, M. B. (2004). Chemically Crosslinked N-Vinyl-2-Pyrrolidone/2-Hydroxyethyl Methacrylate (VP/HEMA) Copolymer for the Controlled Release of Cyclic Oligopeptide. Turkish Journal of Chemistry, Cilt: 28 - Sayı: 3, 279–286. https://ajindex.com/articles/185389

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