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Journals / Turkish Journal of Chemistry / 2004 / Cilt: 28 - Sayı: 3

Chemically Crosslinked N-Vinyl-2-Pyrrolidone/2-Hydroxyethyl Methacrylate (VP/HEMA) Copolymer for the Controlled Release of Cyclic Oligopeptide

Bashir AHMAD
Shumaila BASHIR
Shams-un NISA
M. B. HUGLIN
Pages
279–286
Publication Date
2004-03-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Hydrophilicity, hydrophobicity and monomer composition in the copolymer controlled the drug release from the hydrogels.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Crosslinked copolymers of various compositions of N-vinyl-2-pyrrolidone (VP) and 2-hydroxyethyl methacrylate (HEMA) were prepared chemically in the presence of a crosslinking agent.
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Key Findings & Data:The swelling mechanism was non-Fickian with about 86% conversion of feed composition to crosslinked copolymer.
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Conclusion & Impact:Hydrophilicity, hydrophobicity and monomer composition in the copolymer controlled the drug release from the hydrogels.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:N-vinyl-2-pyrrolidone · 2-hydroxyethyl methacrylate · Hydrogels

Abstract

Crosslinked copolymers of various compositions of N-vinyl-2-pyrrolidone (VP) and 2-hydroxyethyl methacrylate (HEMA) were prepared chemically in the presence of a crosslinking agent. The swelling mechanism was non-Fickian with about 86% conversion of feed composition to crosslinked copolymer. The reactivity ratios r1 = 0.045 and r2 = 3.07 for VP and HEMA indicate that HEMA is more reactive than VP in the reaction. Hydrophilicity, hydrophobicity and monomer composition in the copolymer controlled the drug release from the hydrogels.

Özet

Crosslinked copolymers of various compositions of N-vinyl-2-pyrrolidone (VP) and 2-hydroxyethyl methacrylate (HEMA) were prepared chemically in the presence of a crosslinking agent. The swelling mechanism was non-Fickian with about 86% conversion of feed composition to crosslinked copolymer. The reactivity ratios r1 = 0.045 and r2 = 3.07 for VP and HEMA indicate that HEMA is more reactive than VP in the reaction. Hydrophilicity, hydrophobicity and monomer composition in the copolymer controlled the drug release from the hydrogels.

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Cite This Article

AHMAD, B., BASHIR, S., NISA, S., HUGLIN, M. B. (2004). Chemically Crosslinked N-Vinyl-2-Pyrrolidone/2-Hydroxyethyl Methacrylate (VP/HEMA) Copolymer for the Controlled Release of Cyclic Oligopeptide. Turkish Journal of Chemistry, Cilt: 28 - Sayı: 3, 279–286. https://ajindex.com/articles/185389

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