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Dergiler / Turkish Journal of Chemistry / 2008 / Cilt: 32 - Sayı: 4

One-Step Synthesis of Hyaluronic Acid-Based (Sub)micron Hydrogel Particles: Process Optimization and Preliminary Characterization

Nurettin Sahiner And Xinqiao JIA
Sayfa
397–409
Yayın Tarihi
2008-04-01
DOI
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These HA-based hydrogel particles are promising candidates for use in drug delivery.

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Amaç & Hipotez:Hyaluronic acid (HA)-based (sub)micron hydrogel particles were synthesized by crosslinking virgin HA with divinyl sulfone (DVS) in sodium bis(2-ethylhexyl)sulfosuccinate (AOT) reverse micelle systems under basic conditions.
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Temel Bulgular & Veri:The use of a cosurfactant, 1-heptanol (1-HP), had a profound effect on the reaction kinetics and the particle morphology.
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Sonuç & Katkı:These HA-based hydrogel particles are promising candidates for use in drug delivery.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Hyaluronic acid · (Sub)micron particles · Drug delivery

Özet

Hyaluronic acid (HA)-based (sub)micron hydrogel particles were synthesized by crosslinking virgin HA with divinyl sulfone (DVS) in sodium bis(2-ethylhexyl)sulfosuccinate (AOT) reverse micelle systems under basic conditions. Experimental parameters including HA molecular weight, solution concentration, and reaction time were systematically varied in order to obtain well defined hydrogel particles. The use of a cosurfactant, 1-heptanol (1-HP), had a profound effect on the reaction kinetics and the particle morphology. The resulting particles exhibit negative charges on their surfaces. In vitro biocompatibility study indicates that these particles do not cause severe death to the cultured fibroblasts. These HA-based hydrogel particles are promising candidates for use in drug delivery.

Abstract

Hyaluronic acid (HA)-based (sub)micron hydrogel particles were synthesized by crosslinking virgin HA with divinyl sulfone (DVS) in sodium bis(2-ethylhexyl)sulfosuccinate (AOT) reverse micelle systems under basic conditions. Experimental parameters including HA molecular weight, solution concentration, and reaction time were systematically varied in order to obtain well defined hydrogel particles. The use of a cosurfactant, 1-heptanol (1-HP), had a profound effect on the reaction kinetics and the particle morphology. The resulting particles exhibit negative charges on their surfaces. In vitro biocompatibility study indicates that these particles do not cause severe death to the cultured fibroblasts. These HA-based hydrogel particles are promising candidates for use in drug delivery.

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Bu Makaleye Atıf Yap

JIA, N. S. A. X. (2008). One-Step Synthesis of Hyaluronic Acid-Based (Sub)micron Hydrogel Particles: Process Optimization and Preliminary Characterization. Turkish Journal of Chemistry, Cilt: 32 - Sayı: 4, 397–409. https://ajindex.com/articles/185053

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