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Dergiler / Turkish Journal of Chemistry / 2008 / Cilt: 32 - Sayı: 4

Synthesis and Antimicrobial Activity of Some 3(2H)-Pyridazinone and 1(2H)-Phthalazinone Derivatives

Deniz S. DOĞRUER
Tijen ÖNKOL
Semiha ÖZKAN
Selda ÖZGEN
M. Fethi ŞAHİN
Sayfa
469–479
Yayın Tarihi
2008-04-01
DOI
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Compound 15e had the highest antimycobacterial activity.

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Amaç & Hipotez:Some 3(2H)-pyridazinone and 1(2H)-phthalazinone derivatives were synthesized.
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Temel Bulgular & Veri:The structures of these new compounds were confirmed by IR, 1H-NMR, mass spectrum, and elemental analysis.
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Sonuç & Katkı:Compound 15e had the highest antimycobacterial activity.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:3(2H)-pyridazinone · 1(2H)-phthalazinone · antimicrobial activity

Özet

Some 3(2H)-pyridazinone and 1(2H)-phthalazinone derivatives were synthesized. The structures of these new compounds were confirmed by IR, 1H-NMR, mass spectrum, and elemental analysis. The synthesized compounds were evaluated for their antibacterial activity against various gram-positive and gram-negative strains of bacteria and their clinical isolates and for their antimycobacterial activity against M. tuberculosis H37Rv. The results showed that the synthesized compounds were generally active against B. subtilis and its clinical isolate. Among the target compounds, compound 14c exhibited the best antibacterial activity, with a MIC value of 15.62 m g/mL against B. subtilis. Compound 15e had the highest antimycobacterial activity.

Abstract

Some 3(2H)-pyridazinone and 1(2H)-phthalazinone derivatives were synthesized. The structures of these new compounds were confirmed by IR, 1H-NMR, mass spectrum, and elemental analysis. The synthesized compounds were evaluated for their antibacterial activity against various gram-positive and gram-negative strains of bacteria and their clinical isolates and for their antimycobacterial activity against M. tuberculosis H37Rv. The results showed that the synthesized compounds were generally active against B. subtilis and its clinical isolate. Among the target compounds, compound 14c exhibited the best antibacterial activity, with a MIC value of 15.62 m g/mL against B. subtilis. Compound 15e had the highest antimycobacterial activity.

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Bu Makaleye Atıf Yap

DOĞRUER, D. S., ÖNKOL, T., ÖZKAN, S., ÖZGEN, S., ŞAHİN, M. F. (2008). Synthesis and Antimicrobial Activity of Some 3(2H)-Pyridazinone and 1(2H)-Phthalazinone Derivatives. Turkish Journal of Chemistry, Cilt: 32 - Sayı: 4, 469–479. https://ajindex.com/articles/185039

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