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Dergiler / Turkish Journal of Chemistry / 2009 / Cilt: 33 - Sayı: 6

Antioxidant and anticholinesterase constituents of Salvia poculata

Ufuk KOLAK
Işıl HACIBEKİROĞLU
Mehmet ÖZTÜRK
Fevzi ÖZGÖKÇE
Gülaçtı TOPÇU
Ayhan ULUBELEN
Sayfa
813–823
Yayın Tarihi
2009-06-01
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Ursolic acid (2) and cirsimaritin (4) possessed high butyrylcholinesterase inhibitory activity.

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Amaç & Hipotez:Two triterpenoids, namely 2a,3a-dihydroxy-24-nor- 4(23),12-oleanadien-28-oic acid (1) and ursolic acid (2); 4 flavonoids, namely 5-hydroxy-7,4'-dimethoxyflavone (3), cirsimaritin (4), eupatilin (5), and salvigenin (6); a diterpenoid, namely sclareol (7); and a steroid, namely b-sitosterol (8), were isolated from the aerial parts of Salvia poculata Nab., a Turkish endemic Salvia species.
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Temel Bulgular & Veri:The antioxidant activity of the crude extract and the isolated compounds (2-8) was established using b-carotene bleaching, superoxide anion radical, and ABTS cation radical scavenging activity.
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Sonuç & Katkı:Ursolic acid (2) and cirsimaritin (4) possessed high butyrylcholinesterase inhibitory activity.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Salvia poculata · Lamiaceae · antioxidant activity

Özet

Two triterpenoids, namely 2a,3a-dihydroxy-24-nor- 4(23),12-oleanadien-28-oic acid (1) and ursolic acid (2); 4 flavonoids, namely 5-hydroxy-7,4'-dimethoxyflavone (3), cirsimaritin (4), eupatilin (5), and salvigenin (6); a diterpenoid, namely sclareol (7); and a steroid, namely b-sitosterol (8), were isolated from the aerial parts of Salvia poculata Nab., a Turkish endemic Salvia species. Total phenolic and flavonoid contents of the crude extract were determined as pyrocatechol and quercetin equivalents, respectively. The antioxidant activity of the crude extract and the isolated compounds (2-8) was established using b-carotene bleaching, superoxide anion radical, and ABTS cation radical scavenging activity. In addition, the anticholinesterase activity of the crude extract and the isolated compounds (2-8) against the enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) was determined. The phytochemistry and antioxidant and anticholinesterase activities of S. poculata were investigated for the first time in this study. The crude extract of S. poculata exhibited a significant antioxidant effect as well as butyrylcholinesterase inhibitory activity. Ursolic acid (2) and cirsimaritin (4) possessed high butyrylcholinesterase inhibitory activity.

Abstract

Two triterpenoids, namely 2a,3a-dihydroxy-24-nor- 4(23),12-oleanadien-28-oic acid (1) and ursolic acid (2); 4 flavonoids, namely 5-hydroxy-7,4'-dimethoxyflavone (3), cirsimaritin (4), eupatilin (5), and salvigenin (6); a diterpenoid, namely sclareol (7); and a steroid, namely b-sitosterol (8), were isolated from the aerial parts of Salvia poculata Nab., a Turkish endemic Salvia species. Total phenolic and flavonoid contents of the crude extract were determined as pyrocatechol and quercetin equivalents, respectively. The antioxidant activity of the crude extract and the isolated compounds (2-8) was established using b-carotene bleaching, superoxide anion radical, and ABTS cation radical scavenging activity. In addition, the anticholinesterase activity of the crude extract and the isolated compounds (2-8) against the enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) was determined. The phytochemistry and antioxidant and anticholinesterase activities of S. poculata were investigated for the first time in this study. The crude extract of S. poculata exhibited a significant antioxidant effect as well as butyrylcholinesterase inhibitory activity. Ursolic acid (2) and cirsimaritin (4) possessed high butyrylcholinesterase inhibitory activity.

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Bu Makaleye Atıf Yap

KOLAK, U., HACIBEKİROĞLU, I., ÖZTÜRK, M., ÖZGÖKÇE, F., TOPÇU, G., ULUBELEN, A. (2009). Antioxidant and anticholinesterase constituents of Salvia poculata. Turkish Journal of Chemistry, Cilt: 33 - Sayı: 6, 813–823. https://ajindex.com/articles/185022

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