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Journals / Turkish Journal of Chemistry / 2009 / Cilt: 33 - Sayı: 6

Antioxidant and anticholinesterase constituents of Salvia poculata

Ufuk KOLAK
Işıl HACIBEKİROĞLU
Mehmet ÖZTÜRK
Fevzi ÖZGÖKÇE
Gülaçtı TOPÇU
Ayhan ULUBELEN
Pages
813–823
Publication Date
2009-06-01
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Ursolic acid (2) and cirsimaritin (4) possessed high butyrylcholinesterase inhibitory activity.

📌 3 Key Takeaways

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Objective & Hypothesis:Two triterpenoids, namely 2a,3a-dihydroxy-24-nor- 4(23),12-oleanadien-28-oic acid (1) and ursolic acid (2); 4 flavonoids, namely 5-hydroxy-7,4'-dimethoxyflavone (3), cirsimaritin (4), eupatilin (5), and salvigenin (6); a diterpenoid, namely sclareol (7); and a steroid, namely b-sitosterol (8), were isolated from the aerial parts of Salvia poculata Nab., a Turkish endemic Salvia species.
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Key Findings & Data:The antioxidant activity of the crude extract and the isolated compounds (2-8) was established using b-carotene bleaching, superoxide anion radical, and ABTS cation radical scavenging activity.
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Conclusion & Impact:Ursolic acid (2) and cirsimaritin (4) possessed high butyrylcholinesterase inhibitory activity.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Salvia poculata · Lamiaceae · antioxidant activity

Abstract

Two triterpenoids, namely 2a,3a-dihydroxy-24-nor- 4(23),12-oleanadien-28-oic acid (1) and ursolic acid (2); 4 flavonoids, namely 5-hydroxy-7,4'-dimethoxyflavone (3), cirsimaritin (4), eupatilin (5), and salvigenin (6); a diterpenoid, namely sclareol (7); and a steroid, namely b-sitosterol (8), were isolated from the aerial parts of Salvia poculata Nab., a Turkish endemic Salvia species. Total phenolic and flavonoid contents of the crude extract were determined as pyrocatechol and quercetin equivalents, respectively. The antioxidant activity of the crude extract and the isolated compounds (2-8) was established using b-carotene bleaching, superoxide anion radical, and ABTS cation radical scavenging activity. In addition, the anticholinesterase activity of the crude extract and the isolated compounds (2-8) against the enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) was determined. The phytochemistry and antioxidant and anticholinesterase activities of S. poculata were investigated for the first time in this study. The crude extract of S. poculata exhibited a significant antioxidant effect as well as butyrylcholinesterase inhibitory activity. Ursolic acid (2) and cirsimaritin (4) possessed high butyrylcholinesterase inhibitory activity.

Özet

Two triterpenoids, namely 2a,3a-dihydroxy-24-nor- 4(23),12-oleanadien-28-oic acid (1) and ursolic acid (2); 4 flavonoids, namely 5-hydroxy-7,4'-dimethoxyflavone (3), cirsimaritin (4), eupatilin (5), and salvigenin (6); a diterpenoid, namely sclareol (7); and a steroid, namely b-sitosterol (8), were isolated from the aerial parts of Salvia poculata Nab., a Turkish endemic Salvia species. Total phenolic and flavonoid contents of the crude extract were determined as pyrocatechol and quercetin equivalents, respectively. The antioxidant activity of the crude extract and the isolated compounds (2-8) was established using b-carotene bleaching, superoxide anion radical, and ABTS cation radical scavenging activity. In addition, the anticholinesterase activity of the crude extract and the isolated compounds (2-8) against the enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) was determined. The phytochemistry and antioxidant and anticholinesterase activities of S. poculata were investigated for the first time in this study. The crude extract of S. poculata exhibited a significant antioxidant effect as well as butyrylcholinesterase inhibitory activity. Ursolic acid (2) and cirsimaritin (4) possessed high butyrylcholinesterase inhibitory activity.

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Cite This Article

KOLAK, U., HACIBEKİROĞLU, I., ÖZTÜRK, M., ÖZGÖKÇE, F., TOPÇU, G., ULUBELEN, A. (2009). Antioxidant and anticholinesterase constituents of Salvia poculata. Turkish Journal of Chemistry, Cilt: 33 - Sayı: 6, 813–823. https://ajindex.com/articles/185022

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