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Dergiler / Turkish Journal of Chemistry / 2014 / Cilt: 38 - Sayı: 5

Synthesis of tertiary propargylic phosphonates by addition of trialkynylaluminum reagents to acyl phosphonates and investigation of their antimicrobial activities

Mohammad Shakhawoat HOSSAIN
Sıdıka POLAT ÇAKIR\dag
Ayşe Betül KARADUMAN
Sayfa
880–893
Yayın Tarihi
2014-05-01
DOI
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Compounds 3a and 3h showed noticeable antifungal activity, especially against molds.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:A series of propargylic alcohols containing phosphonates was synthesized by addition reactions of tris-(propynyl) and tris-(phenylethynyl)aluminum reagents to acyl phosphonates in good yields.
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Temel Bulgular & Veri:Aromatic moieties of the acyl phosphonates with electron-withdrawing groups generally resulted in better isolated chemical yield.
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Sonuç & Katkı:Compounds 3a and 3h showed noticeable antifungal activity, especially against molds.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Acyl phosphonates · alkynyl organoaluminum · propargylic alcohols

Özet

A series of propargylic alcohols containing phosphonates was synthesized by addition reactions of tris-(propynyl) and tris-(phenylethynyl)aluminum reagents to acyl phosphonates in good yields. Aromatic moieties of the acyl phosphonates with electron-withdrawing groups generally resulted in better isolated chemical yield. Selected propargylic phosphonates were tested for antimicrobial activities. Compounds 3a and 3h showed noticeable antifungal activity, especially against molds.

Abstract

A series of propargylic alcohols containing phosphonates was synthesized by addition reactions of tris-(propynyl) and tris-(phenylethynyl)aluminum reagents to acyl phosphonates in good yields. Aromatic moieties of the acyl phosphonates with electron-withdrawing groups generally resulted in better isolated chemical yield. Selected propargylic phosphonates were tested for antimicrobial activities. Compounds 3a and 3h showed noticeable antifungal activity, especially against molds.

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Bu Makaleye Atıf Yap

HOSSAIN, M. S., ÇAKIR\dag, S. P., KARADUMAN, A. B. (2014). Synthesis of tertiary propargylic phosphonates by addition of trialkynylaluminum reagents to acyl phosphonates and investigation of their antimicrobial activities. Turkish Journal of Chemistry, Cilt: 38 - Sayı: 5, 880–893. https://ajindex.com/articles/184847

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