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Journals / Turkish Journal of Chemistry / 2014 / Cilt: 38 - Sayı: 5

Synthesis of tertiary propargylic phosphonates by addition of trialkynylaluminum reagents to acyl phosphonates and investigation of their antimicrobial activities

Mohammad Shakhawoat HOSSAIN
Sıdıka POLAT ÇAKIR\dag
Ayşe Betül KARADUMAN
Pages
880–893
Publication Date
2014-05-01
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Compounds 3a and 3h showed noticeable antifungal activity, especially against molds.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:A series of propargylic alcohols containing phosphonates was synthesized by addition reactions of tris-(propynyl) and tris-(phenylethynyl)aluminum reagents to acyl phosphonates in good yields.
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Key Findings & Data:Aromatic moieties of the acyl phosphonates with electron-withdrawing groups generally resulted in better isolated chemical yield.
💡
Conclusion & Impact:Compounds 3a and 3h showed noticeable antifungal activity, especially against molds.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Acyl phosphonates · alkynyl organoaluminum · propargylic alcohols

Abstract

A series of propargylic alcohols containing phosphonates was synthesized by addition reactions of tris-(propynyl) and tris-(phenylethynyl)aluminum reagents to acyl phosphonates in good yields. Aromatic moieties of the acyl phosphonates with electron-withdrawing groups generally resulted in better isolated chemical yield. Selected propargylic phosphonates were tested for antimicrobial activities. Compounds 3a and 3h showed noticeable antifungal activity, especially against molds.

Özet

A series of propargylic alcohols containing phosphonates was synthesized by addition reactions of tris-(propynyl) and tris-(phenylethynyl)aluminum reagents to acyl phosphonates in good yields. Aromatic moieties of the acyl phosphonates with electron-withdrawing groups generally resulted in better isolated chemical yield. Selected propargylic phosphonates were tested for antimicrobial activities. Compounds 3a and 3h showed noticeable antifungal activity, especially against molds.

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Cite This Article

HOSSAIN, M. S., ÇAKIR\dag, S. P., KARADUMAN, A. B. (2014). Synthesis of tertiary propargylic phosphonates by addition of trialkynylaluminum reagents to acyl phosphonates and investigation of their antimicrobial activities. Turkish Journal of Chemistry, Cilt: 38 - Sayı: 5, 880–893. https://ajindex.com/articles/184847

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