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Dergiler / Kafkas Üniversitesi Veteriner Fakültesi Dergisi / 2020 / Cilt: 26 - Sayı: 3

Higenamine Decreased Oxidative Kidney Damage Induced By Ischemia Reperfusion in Rats

Higenamin Ratlarda İskemi Reperfüzyonunun Neden Olduğu Oksidatif Böbrek Hasarını Azaltır

Mustafa CAN GÜLER
Ayhan TANYELİ
ERSEN ERASLAN
Fazile Nur EKİNCİ AKDEMİR
ÖMER TOPDAĞI
Tuncer NACAR
Sayfa
365–370
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

These results have demonstrated that higenamine administration as single dose is effective against oxidative kidney damage originating from ischemia reperfusion.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:The aim of this research is to determine protective effects of higenamine on kidney tissue injury caused by ischemia reperfusion.
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Temel Bulgular & Veri:In this study, 24 Sprague Dawley female rats were divided into 3 groups.
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Sonuç & Katkı:These results have demonstrated that higenamine administration as single dose is effective against oxidative kidney damage originating from ischemia reperfusion.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

The aim of this research is to determine protective effects of higenamine on kidney tissue injury caused by ischemia reperfusion. In this study, 24 Sprague Dawley female rats were divided into 3 groups. The groups were designed as follows; control, ischemia reperfusion, and ischemia reperfusion + higenamine. Some oxidant, antioxidant and inflammatory parameters were evaluated in kidney tissues at the end of the experimental procedure. It was confirmed that the oxidant and inflammatory parameters of kidney tissue increased and antioxidant parameters decreased in ischemia reperfusion group compared to control group. Antioxidant parameters increased while oxidant and inflammatory parameters decreased in the ischemia reperfusion + higenamine group compared to ischemia reperfusion group. These results have demonstrated that higenamine administration as single dose is effective against oxidative kidney damage originating from ischemia reperfusion.

Abstract

Bu araştırmanın amacı, higenaminin, iskemi reperfüzyonunun neden olduğu böbrek dokusu hasarı üzerine koruyucu etkilerini belirlemektir. Bu araştırmada 24 adet Sprague Dawley dişi sıçan üç gruba ayrıldı. Bu çalışmanın grupları aşağıdaki şekilde tasarlanmıştır; kontrol, iskemi reperfüzyon ve iskemi reperfüzyon + higenamin grupları. Deney sonunda elde edilen böbrek dokularındaki bazı oksidan, antioksidan ve inflamatuvar parametreler değerlendirildi. İskemi reperfüzyon grubu kontrol grubu ile kıyaslandığında, böbrek dokusundaki oksidan ve inflamatuvar parametrelerin arttığı fakat antioksidan parametrelerin azaldığı belirlendi. Tedavi grubu (iskemi reperfüzyon + higenamin) yalnızca iskemi reperfüzyon grubu ile kıyaslandığında antioksidan parametreler artarken, oksidan ve inflamatuvar parametreler azaldı. Bu sonuçlar, tek doz higenamin uygulamasının, iskemi reperfüzyon kaynaklı oksidatif böbrek hasarına karşı etkili olduğunu göstermiştir.

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Bu Makaleye Atıf Yap

GÜLER, M. C., TANYELİ, A., ERASLAN, E., AKDEMİR, F. N. E., TOPDAĞI, Ö., NACAR, T. (2020). Higenamine Decreased Oxidative Kidney Damage Induced By Ischemia Reperfusion in Rats. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 26 - Sayı: 3, 365–370. https://ajindex.com/articles/175116

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