Dergiler / Sağlık Bilimleri Üniversitesi Hemşirelik Dergisi / 2026 / Cilt: 8 Sayı: 2

Yüksek Doz Kemoterapi Uygulanan Hematolojik Malignite Hastalarının Yaşam Kalitesinin Değerlendirilmesi: Tanımlayıcı Araştırma

Quality of Life in Patients with Hematological Malignancy Receiving High-Dose Chemotherapy : A Descriptive Study

Seher Çakmak(GÜMÜŞHANE ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ FAKÜLTESİ)0000-0003-4684-8333
Nesrin Nural(KARADENİZ TEKNİK ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ FAKÜLTESİ)0000-0003-2100-7386
Sayfa
133–142
Yayın Tarihi
2026-08-07
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bulgular: Hastaların %51.3’ü 18–50 yaş aralığında, %52.5’i kadın ve %67.1’i lösemi tanılıdır.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Giriş: Hematolojik maligniteler, agresif tedaviler ve buna bağlı komplikasyonlar nedeniyle yaşam kalitesini azaltmaktadır.
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Temel Bulgular & Veri:Amaç: Bu çalışmada, yüksek doz kemoterapi alan hematolojik malignite hastalarının yaşam kalitesini ve etkileyen faktörleri belirlemek amaçlanmıştır.
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Sonuç & Katkı:Bulgular: Hastaların %51.3’ü 18–50 yaş aralığında, %52.5’i kadın ve %67.1’i lösemi tanılıdır.
🔬Tür:Deneysel Tarla Denemesi
📍Kapsam:158 hasta
⚙️Değişkenler:Hematolojik malignite · kemoterapi · sağlıkla ilişkili yaşam kalitesi

Özet

Giriş: Hematolojik maligniteler, agresif tedaviler ve buna bağlı komplikasyonlar nedeniyle yaşam kalitesini azaltmaktadır. Amaç: Bu çalışmada, yüksek doz kemoterapi alan hematolojik malignite hastalarının yaşam kalitesini ve etkileyen faktörleri belirlemek amaçlanmıştır. Yöntem: Bu tanımlayıcı kesitsel çalışma, bir üniversite hastanesinin hematoloji kliniğinde tedavi gören basit rastgele örnekleme yöntemi ile seçilen 158 hasta ile yürütülmüştür. Veriler kişisel bilgi formu ve “European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30)” ölçeği kullanılarak toplanmıştır. Bulgular: Hastaların %51.3’ü 18–50 yaş aralığında, %52.5’i kadın ve %67.1’i lösemi tanılıdır. Yaşam kalitesi ölçeğinde fonksiyonel skala puan ortalaması 74.47±19.92, semptom skalası puan ortalaması 71.31±19.31 ve global yaşam kalitesi puan ortalaması 39.82±26.31 olarak saptanmıştır. Bu bulgular, hastaların fonksiyonel durumlarının görece iyi, semptom yüklerinin yüksek ve global yaşam kalitelerinin düşük olduğunu göstermektedir. Fonksiyonel alt boyutlarda en yüksek puan bilişsel işlevlerde (85.7±18.8), en düşük puan sosyal işlevlerde (68.9±32.5) elde edilmiştir. Lenfoma tanılı hastaların fonksiyonel skala puanları anlamlı düzeyde daha düşük (p=0.002), lösemi tanısı ve kemoterapi öyküsü olan hastaların semptom skala puanları ise anlamlı düzeyde daha yüksek bulunmuştur (sırasıyla p=0.017, p=0.026). Sonuç: Sonuç olarak, hastaların özellikle fiziksel ve sosyal işlev alanlarında olmak üzere yaşam kalitelerinin düşük ve semptom yüklerinin yüksek olduğu belirlenmiştir. Lösemi ve kemoterapi öyküsü olan hastalarda semptom düzeyleri daha yüksek olup, bu durum hematoloji hastalarında semptom kontrolü ve işlevselliğin değerlendirilmesi ihtiyacını vurgulamaktadır.

Abstract

Introduction: Hematological malignancies reduce quality of life due to aggressive treatments and related complications. Aim: The aim of this study was to evaluate the quality of life of hematologic cancer patients receiving high-dose chemotherapy. Methods: This descriptive cross-sectional study was conducted with 158 patients selected by simple random sampling method who were treated in the hematology clinic of a university hospital. Data were collected using a personal information form and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30). Results: 51.3% of the patients were aged 18–50 years, 52.5% were female, and 67.1% had a diagnosis of leukemia. The mean scores of the quality of life scale were 74.47±19.92 for the functional scale, 71.31±19.31 for the symptom scale, and 39.82±26.31 for the global quality of life. These findings indicate that patients had relatively good functional status, high symptom burden, and low overall quality of life. Among the functional subscales, the highest mean score was observed in cognitive functioning (85.7±18.8), while the lowest was in social functioning (68.9±32.5). Patients diagnosed with lymphoma had significantly lower functional scale scores (p=0.002), whereas patients with leukemia and those with a history of chemotherapy had significantly higher symptom scale scores (p=0.017 and p=0.026, respectively). Conclusion: In conclusion, it was determined that patients had a low quality of life, particularly in the areas of physical and social functioning, and a high symptom burden. Higher symptoms in patients with leukemia and prior chemotherapy underscore the need for symptom control and functional assessment.

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Bu Makaleye Atıf Yap

Çakmak, S., Nural, N. (2026). Yüksek Doz Kemoterapi Uygulanan Hematolojik Malignite Hastalarının Yaşam Kalitesinin Değerlendirilmesi: Tanımlayıcı Araştırma. Sağlık Bilimleri Üniversitesi Hemşirelik Dergisi, Cilt: 8 Sayı: 2, 133–142. https://doi.org/10.48071/sbuhemsirelik.1876498

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