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Kanser Hastalarında Oral Mukozitin Önlenmesi ve Tedavisinde Propolisin Etkinliği: Sistematik Bir İnceleme ve Meta-Analiz

The Effectiveness of Propolis In The Prevention And Treatment of Oral Mucositis in Cancer Patients : A Systematic Review And Meta-Analysis

Seher Çakmak(GÜMÜŞHANE ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ FAKÜLTESİ)0000-0003-4684-8333
Sevda Uzun(Gümüşhane Üniversitesi)0000-0002-5954-717X
Sayfa
310–321
Yayın Tarihi
2026-08-13
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bulgular: Meta-analiz kapsamında yer alan 5 çalışmanın sonuçları değerlendirildiğinde, propolis kullanımının kanser hastalarında oral mukozitin önlenmesi ve tedavisinde istatistiksel olarak anlamlı bir etkiye sahip olduğu belirlenmiştir (SMD= -0,944; %95 GA: -1,314 – -0,574; Z = -5,303; p< 0,001).

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Amaç: Oral mukozit, kanser hastalarında en yaygın semptomlardan biridir.
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Temel Bulgular & Veri:Bu çalışma, kanser hastalarında oral mukozitin önlenmesi ve tedavisinde propolisin etkinliğini ortaya koymak amacı ile yapılmıştır.
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Sonuç & Katkı:Bulgular: Meta-analiz kapsamında yer alan 5 çalışmanın sonuçları değerlendirildiğinde, propolis kullanımının kanser hastalarında oral mukozitin önlenmesi ve tedavisinde istatistiksel olarak anlamlı bir etkiye sahip olduğu belirlenmiştir (SMD= -0,944; %95 GA: -1,314 – -0,574; Z = -5,303; p< 0,001).
🔬Tür:Uygulamalı Anket & Alan Araştırması
📍Kapsam:2024 Verileri
⚙️Değişkenler:Kemoterapi · Meta-Analiz · Oral Mukozit

Özet

Amaç: Oral mukozit, kanser hastalarında en yaygın semptomlardan biridir. Propolis, kanser hastalarında oral mukoziti önlemek ve/veya yönetmek amacıyla kullanılmaktadır. Bu çalışma, kanser hastalarında oral mukozitin önlenmesi ve tedavisinde propolisin etkinliğini ortaya koymak amacı ile yapılmıştır. Yöntem: Bu sistematik derleme ve meta-analiz için literatür taraması Kasım 2024’e kadar, yıl sınırlaması yapılmaksızın PubMed, Web of Science, EBSCOhost, Google Akademik ve Yükseköğretim Kurulu (YÖK) Tez Merkezi veri tabanlarında gerçekleştirilmiştir. Tarama sonucunda elde edilen çalışmalar dahil edilme ve dışlanma kriterlerine göre değerlendirilmiş ve toplam 5 araştırma meta-analize dâhil edilmiştir. Verilerin sentezinde meta-analiz ve öyküsel anlatım yöntemleri kullanılmıştır. Bulgular: Meta-analiz kapsamında yer alan 5 çalışmanın sonuçları değerlendirildiğinde, propolis kullanımının kanser hastalarında oral mukozitin önlenmesi ve tedavisinde istatistiksel olarak anlamlı bir etkiye sahip olduğu belirlenmiştir (SMD= -0,944; %95 GA: -1,314 – -0,574; Z = -5,303; p< 0,001). Heterojenlik analizi sonucunda I² = %54,9 bulunmuş olup çalışmalar arasında orta düzeyde heterojenlik olduğu görülmüştür. Etki büyüklüğü hesaplamalarında Cohen’s d yöntemi kullanılmış ve rastgele etkiler modeline göre ortalama etki büyüklüğü ES= -0,944 olarak hesaplanmıştır. Cohen’in etki büyüklüğü sınıflamasına göre bu değer geniş düzeyde etkiyi göstermektedir. Bu sonuçlar, propolis kullanılan gruplarda oral mukozitin önlenmesi ve tedavisinin kontrol gruplarına kıyasla daha etkili olduğunu ortaya koymaktadır. Sonuç: Bu çalışma, kanser hastalarında oral mukozitin önlenmesi ve yönetiminde doğal bir ürün olan propolisin potansiyel olarak yararlı bir destekleyici yaklaşım olabileceğini göstermektedir. Bununla birlikte, propolisin klinik etkinliğinin daha güçlü kanıtlarla ortaya konabilmesi için daha büyük örneklemli ve iyi tasarlanmış randomize kontrollü çalışmalara ihtiyaç bulunmaktadır. Ayrıca, propolisin güvenli kullanımına ilişkin kanıta dayalı klinik rehberlerin geliştirilmesi, destekleyici bakım uygulamalarının güçlendirilmesine katkı sağlayabilir.

Abstract

Objective: Oral mucositis is one of the most common symptoms in cancer patients. Propolis is utilized for the prevention or management of oral mucositis in these patients. This study was conducted to determine the efficacy of propolis in the prevention and treatment of oral mucositis in cancer patients. Methods: For this systematic review and meta-analysis, a literature search was conducted up to November 2024, without any year restriction, in the PubMed, Web of Science, EBSCOhost, Google Scholar, and the Council of Higher Education (CHE) Thesis Center databases. The studies retrieved from the search were evaluated according to the inclusion and exclusion criteria, and a total of five studies were included in the meta-analysis. Meta-analysis and narrative synthesis methods were used to synthesize the data. Results: When the results of the five studies included in the meta-analysis were evaluated, propolis use was found to have a statistically significant effect on the prevention and treatment of oral mucositis in patients with cancer (SMD = -0.944; 95% CI: -1.314 to -0.574; Z = -5.303; p < 0.001). The heterogeneity analysis showed I² = 54.9%, indicating a moderate level of heterogeneity among the studies. Cohen’s d method was used to calculate the effect size, and according to the random-effects model, the mean effect size was calculated as ES = -0.944. According to Cohen’s effect size classification, this value indicates a large effect. These findings demonstrate that the prevention and treatment of oral mucositis were more effective in the propolis groups compared to the control groups. Conclusion: This study suggests that propolis, a natural product, may serve as a potentially beneficial supportive approach in the prevention and management of oral mucositis in patients with cancer. However, larger sample-sized and well-designed randomized controlled trials are needed to provide stronger evidence regarding the clinical effectiveness of propolis. Furthermore, the development of evidence-based clinical guidelines on the safe use of propolis may contribute to strengthening supportive care practices.

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Bu Makaleye Atıf Yap

Çakmak, S., Uzun, S. (2026). Kanser Hastalarında Oral Mukozitin Önlenmesi ve Tedavisinde Propolisin Etkinliği: Sistematik Bir İnceleme ve Meta-Analiz. Ege Üniversitesi Hemşirelik Fakültesi Dergisi, Cilt: 42 Sayı: 2, 310–321. https://doi.org/10.53490/egehemsire.1659209

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