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Dergiler / International Journal of Chemistry and Technology / 2026 / Volume: 8 Issue: 1

Determination of Antimicrobial, Anticarcinogenic Activity of Bioactive Components of Hypericum Perforatum L. Plant

Osman Bedrettin Akkaya(Kahramanmaraş Sütçü İmam Üniversitesi)0000-0002-8606-881X
İbrahim Seyfettin Çelik(Kahramanmaraş Sütçü İmam Üniversitesi)0000-0001-6946-4477
Erdal Ertaş(KİLİS 7 ARALIK ÜNİVERSİTESİ)0000-0002-4043-5960
Nazan Çömlekcioğlu(Kahramanmaraş Sütçü İmam Üniversitesi)0000-0001-7729-5271
Ashabil Aygan(Kahramanmaraş Sütçü İmam Üniversitesi)0000-0003-4936-9872
Sayfa
—
Yayın Tarihi
2024-06-05
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

It was observed that H. perforatum extracts killed cancer cells at concentrations of 0.1 mg mL-1 and above on H1299, MCF-7 and HUVEC cancer cell lines.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Hypericum perforatum L. (St John's wort), although primarily utilized in traditional medicine, is also frequently employed in modern therapy.
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Temel Bulgular & Veri:Following the GC-MS analysis of the extracts, a total of 18 distinct fatty acids were identified.
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Sonuç & Katkı:It was observed that H. perforatum extracts killed cancer cells at concentrations of 0.1 mg mL-1 and above on H1299, MCF-7 and HUVEC cancer cell lines.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:1st H1299 · 2nd bioactive compounds · 3rd anticarcinogenic activity

Abstract

Hypericum perforatum L. (St John's wort), although primarily utilized in traditional medicine, is also frequently employed in modern therapy. Within the scope of the study, H. perforatum was collected from Kahramanmaraş region and dried. Extracts derived from above-ground parts were analyzed to determine their levels of total phenolic and flavonoid compounds, as well as their antioxidant, anticancer and antimicrobial properties. Following the GC-MS analysis of the extracts, a total of 18 distinct fatty acids were identified. The main fatty acid components were identified as behenic (37.90 %), linoleic (21.22 %), gamma-linolenic (15.87 %), oleic (9.45 %) and palmitic acid (7.64 %). The plant extracts were found to have a total phenolic content of 60.22 mg GAE g-1 and a flavonoid content of 7.68 µg QE g-1, as determined through analysis. Additionally, FRAP and IC50 values were determined as 26.96 µg AAE g-1 and 0.44 µg mL-1, respectively. The antimicrobial activities of H. perforatum extracts were investigated among a total of 11 microorganisms, including 9 bacteria and 2 yeasts. It has been observed that extracts possess significant antimicrobial activity against all tested microorganisms. H. perforatum extracts were observed to have dose-dependent inhibition of all organisms. It was observed that H. perforatum extracts killed cancer cells at concentrations of 0.1 mg mL-1 and above on H1299, MCF-7 and HUVEC cancer cell lines.

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Bu Makaleye Atıf Yap

Akkaya, O. B., Çelik, İ. S., Ertaş, E., Çömlekcioğlu, N., Aygan, A. (2024). Determination of Antimicrobial, Anticarcinogenic Activity of Bioactive Components of Hypericum Perforatum L. Plant. International Journal of Chemistry and Technology, Volume: 8 Issue: 1. https://doi.org/10.32571/ijct.1445857

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