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Dergiler / Afyon Kocatepe Üniversitesi Fen ve Mühendislik Bilimleri Dergisi / 2026 / Cilt: 26 Sayı: 2

3-Alkil(aril)-4-Amino-1,2,4-Triazol-5-on Temelli Suksinamid Türevlerinin Sentezi ve Biyoaktiviteleri: Amid ve N-Mannich Bileşikleri

Synthesis and Bioactivities of 3-Alkyl(aryl)-4-Amino-1,2,4-Triazol-5-ones Based Succinamide Derivatives: Amide and N-Mannich Compounds

Songül Ulufer Bulut(KAFKAS ÜNİVERSİTESİ)0000-0001-9533-0165
Haydar Yüksek(KAFKAS ÜNİVERSİTESİ)0000-0003-1289-1800
Sayfa
322–336
Yayın Tarihi
2026-03-27
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bu çalışma, triazol türevlerinin önemli biyolojik potansiyele sahip olduğunu ve fonksiyonel grup modifikasyonlarıyla biyolojik aktivitelerinin artırılabileceğini ortaya koymaktadır.

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Amaç & Hipotez:1,2,4-Triazoller, yüksek terapötik potansiyelleriyle tanınmakta ve kimyasal stabiliteleri ile çeşitli biyolojik hedeflerle etkileşim kurma özellikleri sayesinde ilaç geliştirmede önemli bir rol oynamaktadır.
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Temel Bulgular & Veri:Bu çalışmada, 3-alkil(aril)-4-amino-4,5-dihidro-1H-1,2,4-triazol-5-on bileşikleri Suksinil Klorür ile reaksiyona sokularak altı adet N,N'-di[3-alkil(aril)-4,5-dihidro-1H-1,2,4-triazol-5-on-4-il]suksinamid türevi sentezlenmiştir.
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Sonuç & Katkı:Bu çalışma, triazol türevlerinin önemli biyolojik potansiyele sahip olduğunu ve fonksiyonel grup modifikasyonlarıyla biyolojik aktivitelerinin artırılabileceğini ortaya koymaktadır.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:5-Dihidro-1H-1 · 4-triazon-5-on · Amid

Özet

1,2,4-Triazoller, yüksek terapötik potansiyelleriyle tanınmakta ve kimyasal stabiliteleri ile çeşitli biyolojik hedeflerle etkileşim kurma özellikleri sayesinde ilaç geliştirmede önemli bir rol oynamaktadır. Bu çalışmada, 3-alkil(aril)-4-amino-4,5-dihidro-1H-1,2,4-triazol-5-on bileşikleri Suksinil Klorür ile reaksiyona sokularak altı adet N,N'-di[3-alkil(aril)-4,5-dihidro-1H-1,2,4-triazol-5-on-4-il]suksinamid türevi sentezlenmiştir. Bu türevler, formaldehit ve morfolin kullanılarak Mannich reaksiyonu ile modifiye edilmiş ve üç adet N-Mannich türevi elde edilmiştir. Sentezlenen dokuz bileşiğin yapısal karakterizasyonu IR, 1H-NMR ve 13C-NMR spektroskopisiyle gerçekleştirilmiştir. Biyolojik değerlendirmeler sırasında, indirgeme gücü, serbest radikal giderme kapasitesi ve metal şelatlama aktivitesi gibi antioksidan özellikler incelenmiştir. Bileşiklerin antioksidan etkilerinin genelde zayıf olduğu belirlenmiştir. Agar kuyucuk yöntemi kullanılarak Bacillus cereus, Klebsiella pneumoniae, Staphylococcus aureus, Serratia marcescens ve Candida albicans gibi patojen mikroorganizmalara karşı yapılan antimikrobiyal aktivite testleri, bazı bileşiklerin güçlü antimikrobiyal özelliklere sahip olduğunu göstermiştir. Bu çalışma, triazol türevlerinin önemli biyolojik potansiyele sahip olduğunu ve fonksiyonel grup modifikasyonlarıyla biyolojik aktivitelerinin artırılabileceğini ortaya koymaktadır.

Abstract

1,2,4-Triazoles, recognized for their remarkable therapeutic potential, play a significant role in drug development due to their chemical stability and interaction with various biological targets. In this study, 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-one compunds were reacted with Succinyl Chloride to produce six N,N'-di[3-alkyl(aryl)-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl]succinylamide derivatives. These derivatives were further modified via the Mannich reaction with formaldehyde and morpholine, yielding three N-Mannich derivatives. Structural characterization of nine synthesized compounds was performed using IR, 1H-NMR and 13C-NMR spectroscopy. Biological evaluations focused on antioxidant properties, including reducing power, free radical scavenging capacity, and metal chelating activity. The antioxidant effects of the compounds were found to be generally weak. Antimicrobial activity tests, performed against Bacillus cereus, Klebsiella pneumoniae, Staphylococcus aureus, Serratia marcescens, and Candida albicans using the agar well diffusion method, revealed that some compounds exhibited strong antimicrobial properties. This study emphasizes the significant biological potential of triazole derivatives, suggesting that their bioactivity can be further enhanced through functional group modifications.

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Bu Makaleye Atıf Yap

Bulut, S. U., Yüksek, H. (2026). 3-Alkil(aril)-4-Amino-1,2,4-Triazol-5-on Temelli Suksinamid Türevlerinin Sentezi ve Biyoaktiviteleri: Amid ve N-Mannich Bileşikleri. Afyon Kocatepe Üniversitesi Fen ve Mühendislik Bilimleri Dergisi, Cilt: 26 Sayı: 2, 322–336. https://doi.org/10.35414/akufemubid.1628344

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