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Dergiler / Karadeniz Chemical Science and Technology / 2018 / Sayı: 3

Bazı yeni 3-alkil(aril)-4-(3-metoksi-4-sinnamoiloksi)benzilidenamino-4,5- dihidro-1H-1,2,4-triazol-5-on bileşiklerinin sentezi, antioksidan ve asitlik özelliklerinin incelenmesi

Synthesis, antioxidant and acidic properties of some new 3-alkyl(aryl)-4-(3- methoxy-4-cinnamoyloxy)benzylideneamino-4,5-dihydro-1H-1,2,4-triazol5-ones

Haydar Yüksek(KAFKAS ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ)0000-0003-1289-1800
Buket Göksu(KAFKAS ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ)0000-0001-8207-967X
Bahar Bankoğlu(KAFKAS ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ)0000-0002-2931-077X
Songül Ulufer(KAFKAS ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ)0000-0001-9533-0165
Sevda Manap(KAFKAS ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ)0000-0002-5025-9622
Murat Beytur(KAFKAS ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ)0000-0002-7098-5592
Özlem Gürsoy Kol(KAFKAS ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ)0000-0003-2637-9023
Sayfa
1–6
Yayın Tarihi
2018-12-31
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

HNP ve pKa değerlerinin çözücüye ve 4,5-dihidro-1H-1,2,4-triazol-5-on yapısında C-3 pozisyonundaki substutiente bağlı değiştiği gözlendi.

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Amaç & Hipotez:3-Alkil(aril)-4-amino-4,5-dihidro-1H-1,2,4-triazol-5-on (2) bileşiklerinin, 3-metoksi-4-sinnamoiloksibenzaldehid (3) ile reaksiyonları sonucunda dokuz yeni 3-alkil(aril)-4-(3-metoksi-4-sinnamoiloksi)-benzilidenamino-4,5-dihidro-1H-1,2,4-triazol5-on (4) bileşikleri sentezlendi.
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Temel Bulgular & Veri:Yeni dokuz adet bileşiğin yapısı IR, 1H-NMR, 13C-NMR ve UV spektrum verileri ile aydınlatıldı.
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Sonuç & Katkı:HNP ve pKa değerlerinin çözücüye ve 4,5-dihidro-1H-1,2,4-triazol-5-on yapısında C-3 pozisyonundaki substutiente bağlı değiştiği gözlendi.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:4-Triazol-5-on · sentez · Schiff bazı

Özet

3-Alkil(aril)-4-amino-4,5-dihidro-1H-1,2,4-triazol-5-on (2) bileşiklerinin, 3-metoksi-4-sinnamoiloksibenzaldehid (3) ile reaksiyonları sonucunda dokuz yeni 3-alkil(aril)-4-(3-metoksi-4-sinnamoiloksi)-benzilidenamino-4,5-dihidro-1H-1,2,4-triazol5-on (4) bileşikleri sentezlendi. Yeni dokuz adet bileşiğin yapısı IR, 1H-NMR, 13C-NMR ve UV spektrum verileri ile aydınlatıldı. Sentezlenen bileşiklerin in vitro antioksidan aktiviteleri üç farklı yöntemle analiz edildi. Ayrıca, çözücülerin ve moleküler yapının asitlik üzerine etkisini incelemek için, 4 bileşikleri dört farklı çözücüde (izopropil alkol, tert-butil alkol, aseton ve N,Ndimetilformamid) tetrabutilamonyum hidroksid ile potansiyometrik metotla titre edildi. HNP ve pKa değerlerinin çözücüye ve 4,5-dihidro-1H-1,2,4-triazol-5-on yapısında C-3 pozisyonundaki substutiente bağlı değiştiği gözlendi.

Abstract

Nine new 3-alkyl(aryl)-4-(3-methoxy-4-cinnamoyloxy)benzylideneamino-4,5-dihydro-1 H -1,2,4-triazol-5-ones ( 4 ) were synthesized by the reactions of 3-alkyl(aryl)-4-amino-4,5-dihydro-1 H -1,2,4-triazol-5-ones ( 2 ) with 3-methoxy-4-cinnamoyloxybenzaldehyde ( 3 ) . The structures of new nine compounds were established from IR, 1 H-NMR, 13 C-NMR and UV spectral data. The synthesized compounds were analyzed for their in vitro potential antioxidant activities in three different methods. In addition, to investigate the effects of solvents and molecular structure upon acidity compounds 4 were titrated potentiometrically with tetrabutylammonium hydroxide in four non-aqueous solvents (isopropyl alcohol, tert-butyl alcohol, acetone and N , N -dimethylformamide).

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Bu Makaleye Atıf Yap

Yüksek, H., Göksu, B., Bankoğlu, B., Ulufer, S., Manap, S., Beytur, M., Kol, Ö. G. (2018). Bazı yeni 3-alkil(aril)-4-(3-metoksi-4-sinnamoiloksi)benzilidenamino-4,5- dihidro-1H-1,2,4-triazol-5-on bileşiklerinin sentezi, antioksidan ve asitlik özelliklerinin incelenmesi. Karadeniz Chemical Science and Technology, Sayı: 3, 1–6. https://ajindex.com/articles/1002266

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