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Electrophysiological and Histopathological Effects of Minoxidil on Penicillin-Induced Epilepsy Model in Rats

Ayhan Çetinkaya(BOLU ABANT IZZET BAYSAL UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-8212-7149
Serhat Gokdaş(BOLU ABANT IZZET BAYSAL UNIVERSITY)0000-0001-6749-3522
Hayriye Soytürk(BOLU ABANT IZZET BAYSAL UNIVERSITY)0000-0001-5971-7362
Tülin Fırat(BOLU ABANT IZZET BAYSAL UNIVERSITY)0000-0002-8317-7092
Esra Fidan Karamaden(BOLU ABANT IZZET BAYSAL UNIVERSITY)0000-0003-4050-9699
Sayfa
167–177
Yayın Tarihi
2025-12-30
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Nevertheless, future research should concentrate on well-designed studies with larger sample sizes to acquire more robust and generalisable evidence.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: Less is known about Kir6.1 ion channel opener minoxidil on the pathogenesis of epilepsy.
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Temel Bulgular & Veri:This experimental study aimed to investigate the electrophysiological and histopathological effects of Kir6.1 ion channel opener Minoxidil on penicillin-induced epilepsy model in rats.
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Sonuç & Katkı:Nevertheless, future research should concentrate on well-designed studies with larger sample sizes to acquire more robust and generalisable evidence.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Minoxidil · Epilepsy · Rat

Abstract

Objective: Less is known about Kir6.1 ion channel opener minoxidil on the pathogenesis of epilepsy. This experimental study aimed to investigate the electrophysiological and histopathological effects of Kir6.1 ion channel opener Minoxidil on penicillin-induced epilepsy model in rats. Materials and Methods: The present study comprised a total of 42 male Wistar rats. The rats were randomly divided into six groups: control (n=7), minox (n=7), Epilepsy (n=7), Eminox (n=7), DIA (n=7), and DMSO (n=7). Intracranial administration of penicillin was performed in the study groups to induce experimental epilepsy. Epileptiform activities were recorded in all animals and subsequently compared prospectively between the experimental groups. Results: The values of spike-wave frequency and amplitude were significantly higher in the epilepsy group than in control, DMSO, and Minox groups. Conversely, staining differences were observed between groups in histopathological findings, but this was not significant enough to be evaluated statistically. Conclusion: Our study demonstrated that minoxidil administration had no any significant electrophysiological and histopathological effects on triggering epilepsy. Nevertheless, future research should concentrate on well-designed studies with larger sample sizes to acquire more robust and generalisable evidence.

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Bu Makaleye Atıf Yap

Çetinkaya, A., Gokdaş, S., Soytürk, H., Fırat, T., Karamaden, E. F. (2025). Electrophysiological and Histopathological Effects of Minoxidil on Penicillin-Induced Epilepsy Model in Rats. Abant Tıp Dergisi, Cilt: 14 Sayı: 3, 167–177. https://doi.org/10.47493/abantmedj.1686860

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