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Dergiler / Abant Tıp Dergisi / 2026 / Cilt: 15 Sayı: 2

Prenatal Diagnosis of Iniencephaly Apertus and Clausus in the First and Third Trimesters: Case Reports and Review of the Literature

Serdar Aykut(Çukurova Üniversitesi)0000-0002-6590-9982
Ayşe Büşra Önder(Mardin Eğitim ve Araştırma Hastanesi)0000-0003-4170-3768
İbrahim Batmaz(Artuklu Üniversitesi Tıp Fakültesi)0000-0001-9492-2783
Deniz Balsak(Artuklu Üniversitesi Tıp Fakültesi)0009-0004-3533-3443
Emre Yalçin(çukurova üniversitesi)0000-0001-7088-6749
Sayfa
219–225
Yayın Tarihi
2026-08-28
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Herein, we present two prenatally diagnosed cases: one of iniencephaly apertus detected in the first trimester and one of iniencephaly clausus diagnosed in the third trimester.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Iniencephaly is a rare and severe neural tube defect characterized by an occipital bone defect, partial or complete absence of the cervicothoracic vertebrae, and marked hyperextension of the fetal head.
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Temel Bulgular & Veri:Its reported incidence ranges between 0.0001% and 0.01%, with a significantly higher prevalence in female fetuses.
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Sonuç & Katkı:Herein, we present two prenatally diagnosed cases: one of iniencephaly apertus detected in the first trimester and one of iniencephaly clausus diagnosed in the third trimester.
🔬Tür:Olgu Sunumu
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Iniencephaly · Neural Tube Defects · Prenatal Diagnosis

Abstract

Iniencephaly is a rare and severe neural tube defect characterized by an occipital bone defect, partial or complete absence of the cervicothoracic vertebrae, and marked hyperextension of the fetal head. Its reported incidence ranges between 0.0001% and 0.01%, with a significantly higher prevalence in female fetuses. Iniencephaly is classified into two types: iniencephaly apertus and iniencephaly clausus. As a neural tube defect, preconceptional folic acid supplementation plays a crucial role in its prevention. Early prenatal diagnosis is essential for appropriate counseling and management, particularly given that the condition is generally incompatible with life. Timely identification allows consideration of pregnancy termination, thereby reducing potential maternal morbidity and psychological burden. Herein, we present two prenatally diagnosed cases: one of iniencephaly apertus detected in the first trimester and one of iniencephaly clausus diagnosed in the third trimester.

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Bu Makaleye Atıf Yap

Aykut, S., Önder, A. B., Batmaz, İ., Balsak, D., Yalçin, E. (2026). Prenatal Diagnosis of Iniencephaly Apertus and Clausus in the First and Third Trimesters: Case Reports and Review of the Literature. Abant Tıp Dergisi, Cilt: 15 Sayı: 2, 219–225. https://doi.org/10.47493/abantmedj.1956702

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Kaynakça (19)

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