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Dergiler / The Turkish Journal of Ear Nose and Throat / 2026 / Volume: 33 Issue: 2

Evaluation of Possible Alterations in The Auditory Evoked and Event-Related Potentials in Patients with Tinnitus

Mustafa Altıntaş(University of Health Science, Antalya Training and Research Hospital, Department of Otolaryngology)0000-0002-9846-5513
Enis Hidisoglu(Turin University, Department of Drug Science and Technology)0000-0002-1729-1209
Sayfa
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Yayın Tarihi
2023-06-22
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: Our results indicate that tinnitus leads to a deficit in the neural networks of the auditory sensory memory, and the MMN amplitude may serve as an objective biomarker for assessing tinnitus.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: Tinnitus is a very common health problem and is reported in all age groups.
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Temel Bulgular & Veri:The ability to objectively assess tinnitus complaints could provide significant benefits to treat or prevent its progress.
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Sonuç & Katkı:Conclusion: Our results indicate that tinnitus leads to a deficit in the neural networks of the auditory sensory memory, and the MMN amplitude may serve as an objective biomarker for assessing tinnitus.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Tinnitus · auditory sensory processing · evoked and event-related potentials

Abstract

Objective: Tinnitus is a very common health problem and is reported in all age groups. The ability to objectively assess tinnitus complaints could provide significant benefits to treat or prevent its progress. In this study, we aimed to identify reliable electrophysiological biomarkers for tinnitus comparing by auditory evoked potential (AEPs), auditory event related potentials (AERPs), and mismatch negativity (MMN) responses between patients with tinnitus and healthy controls. Materials and Methods: This study included ten subjects with tinnitus and ten age and sex-matched healthy controls. All participants gave informed consent forms and were evaluated through basic audiology evaluation, the Tinnitus Handicap Inventory for a structured diagnostic interview and tinnitus severity, and electrophysiological tests. Electrophysiological data were collected from 32 surface scalp electrodes using different frequencies of stimulus for AEPs and the oddball paradigm for AERPs and MMN. Results: The components of AEPs for auditory stimulus with different frequencies, the components of AERPs for standard (StbD) and deviant (Dev) tones, and the difference wave (MMN) were compared between the two groups. Neither AEPs components in auditory stimulus with different frequencies, nor the AERPs components for StbD and Dev tones were affected by tinnitus (p>0.05 for all comparisons). However, the MMN amplitude was significantly decreased in the tinnitus group compared to the control group on the left front (p<0.001), right front (p<0.01), and left back (p<0.01) brain regions, while no significant changes were observed in MMN latency between the two groups. Conclusion: Our results indicate that tinnitus leads to a deficit in the neural networks of the auditory sensory memory, and the MMN amplitude may serve as an objective biomarker for assessing tinnitus.

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Bu Makaleye Atıf Yap

Altıntaş, M., Hidisoglu, E. (2023). Evaluation of Possible Alterations in The Auditory Evoked and Event-Related Potentials in Patients with Tinnitus. The Turkish Journal of Ear Nose and Throat, Volume: 33 Issue: 2. https://ajindex.com/articles/1329206

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Kaynakça (27)

  1. Konadath S, P. Manjula. Auditory brainstem response and late latency response in individuals with tinnitus having normal hearing. Intractable Rare Dis Res 2016;5(4):262-8. google scholar
  2. Oosterloo BC, PH Croll, Baatenburg de Jong RJ, Ikram MK, Goedegebure A. Prevalence of tinnitus in an aging population and its relation to age and hearing loss. Otolaryngol Head Neck Surg 2021;164(4):859-68. google scholar
  3. Haider HF, Bojic T, Ribeiro SF, Paco J, Hall DA, Szczepek AJ. Pathophysiology of subjective tinnitus: Triggers and Maintenance. Front Neurosci 2018;12:866. google scholar
  4. Gabr TA, El-Hay MA, Badawy A. Electrophysiological and psychological studies in tinnitus. Auris Nasus Larynx 2011;38(6):678-83. google scholar
  5. Melcher JR, NY Kiang. Generators of the brainstem auditory evoked potential in cat. III: Identified cell populations. Hear Res 1996;93(1-2):52-71. google scholar
  6. Milloy VP, Fournier P, Benoit D, Norena A, Koravand A. Auditory brainstem responses in tinnitus: a review of who, how, and what? Front Aging Neurosci 2017;9:237. google scholar
  7. Aksoy S, Fırat Y, Alpar R. The tinnitus handicap inventory: a study of validity and reliability. Int Tinnitus J 2007;13(2):94-8. google scholar
  8. Tadel F, Baillet S, Mosher JC, Pantazis D, Leahy RM. Brainstorm: a user-friendly application for MEG/EEG analysis. Comput Intell Neurosci 2011;2011:879716. google scholar
  9. Arslan E, Prosser S, Michelini S. Simultaneous recording of auditory evoked potentials. Relationships among the fast, middle and long latency components. Scand Audiol 1984;13(2):75-81. google scholar
  10. Korzyukov O, Pflieger ME, Wagner M, Bowyer SM, Rosburg T, Sundaresan K, et al. Generators of the intracranial P50 response in auditory sensory gating. Neuroimage 2007;35(2):814-26. google scholar
  11. Sanders LD, Astheimer LB. Temporally selective attention modulates early perceptual processing: event-related potential evidence. Percept Psychophys 2008;70(4):732-42. google scholar
  12. Naatanen R, Paavilainen P, Alho K, Reinikainen K, Sams M. The mismatch negativity to intensity changes in an auditory stimulus sequence. Electroencephalogr Clin Neurophysiol Suppl 1987;40:125-31. google scholar
  13. Joos K, Gilles A, Van de Heyning P, De Ridder D, Vanneste S. From sensation to percept: the neural signature of auditory event-related potentials. Neurosci Biobehav Rev 2014;42:148-56. google scholar
  14. Norena A, Cransac H, Chery-Croze S. Towards an objectification by classification of tinnitus. Clin Neurophysiol 1999;110(4):666-75. google scholar
  15. Santos Filha VA, Matas CG. Late Auditory evoked potentials in individuals with tinnitus. Braz J Otorhinolaryngol 2010;76(2):263-70. google scholar
  16. Cardon E, Joossen I, Vermeersch H, Jacquemin L, Mertens G, Vanderveken OM, et al. Systematic review and meta-analysis of late auditory evoked potentials as a candidate biomarker in the assessment of tinnitus. PLoS One 2020;15(12):e0243785. google scholar
  17. Eman AS. Electrophysiological differences in sensorineural hearing loss patients with and without problem-tinnitus. EJO 2012;28:22-34. google scholar
  18. Friedman D, Vaughan HG Jr, Erlenmeyer-Kimling L. Stimulus and response related components of the late positive complex in visual discrimination tasks. Electroencephalogr Clin Neurophysiol 1978;45(3):319-30. google scholar
  19. Sutton, S, Braren M, Zubin J, John ER. Evoked-potential correlates of stimulus uncertainty. Science 1965;150(3700):1187-8. google scholar
  20. Houdayer E, Teggi R, Velikova S, Gonzalez-Rosa JJ, Bussi M, Comi G, et al. Involvement of cortico-subcortical circuits in normoacousic chronic tinnitus: A source localization EEG study. Clin Neurophysiol 2015;126(12):2356-65. google scholar
  21. Attias J, Urbach D, Gold S, Shemesh Z. Auditory event related potentials in chronic tinnitus patients with noise induced hearing loss. Hear Res 1993;71(1-2):106-13. google scholar
  22. Majhi SK, Khandelwal K, Shrivastava MK. Tinnitus and Cognition: Linked? Indian J Otolaryngol Head Neck Surg 2019;71(Suppl 2):1426-30. google scholar
  23. Naatanen R, Gaillard AW, Mantysalo S. Early selective-attention effect on evoked potential reinterpreted. Acta Psychol (Amst) 1978;42(4):313-29. google scholar
  24. Yang H, Xiong H, Yu R, Wang C, Zheng Y, Zhang X. The characteristic and changes of the event-related potentials (ERP) and brain topographic maps before and after treatment with rTMS in subjective tinnitus patients. PLoS One 2013;8(8):e70831. google scholar
  25. Mahmoudian S, Farhadi M, Najafi-Koopaie M, Darestani-Farahani E, Mohebbi M, Dengler R, et al. Central auditory processing during chronic tinnitus as indexed by topographical maps of the mismatch negativity obtained with the multi-feature paradigm. Brain Res 2013;1527:161-73. google scholar
  26. Sendesen E, Erbil N, Türkyılmaz MD. The mismatch negativity responses of individuals with tinnitus with normal extended high-frequency hearing-is it possible to use mismatch negativity in the evaluation of tinnitus? Eur Arch Otorhinolaryngol 2022;279(7):3425-34. google scholar
  27. El-Minawi MS, Dabbous AO, Hamdy MM, Sheta SM. Does changes in mismatch negativity after tinnitus retraining therapy using tinnitus pitch as deviant stimulus, reflect subjective improvement in tinnitus handicap? Hearing, Balance and Communication 2018;16(3):182-96. google scholar