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Dergiler / Meandros Medical And Dental Journal / 2026 / Volume: 26 Issue: 1

Alkolik Olmayan Yağlı Karaciğer Hastalığının Evrelerinde Enflamasyon Oranlarının (Nötrofil/Lenfosit) ve Hemogram Sonuçlarının Araştırılması

Investigation of Inflammation Rates (Neutrophil/Lymphocyte) and Hemogram Results in the Stages of Non-Alcoholic Fatty Liver Disease

Mehmet Ali Gül(AMASYA UNIVERSITY)0000-0002-5849-0116
Duygu Tozcu Yılmaz(AMASYA UNIVERSITY)0000-0002-3972-5442
Mustafa Çapraz(AMASYA UNIVERSITY)0000-0001-9586-6509
Sayfa
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Yayın Tarihi
2025-03-20
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bulgular: Hastalık evreleri ilerledikçe (G3), MPV değerlerinde anlamlı bir azalma (p=0,005*) ve NLR değerlerinde anlamlı bir artış (p 0,05), MCH (p>0,05), PDW (p>0,05), PCT (p>0,05), MONO (p>0,05) ve EO (p>0,05) parametrelerinde istatistiksel olarak anlamlı bir fark bulunmamıştır.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Giriş: Non-alkolik yağlı karaciğer hastalığı (NAYKH), karaciğerde anormal düzeyde yağ birikimi ve buna eşlik eden enflamasyonla karakterize kronik bir durumdur.
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Temel Bulgular & Veri:Bu çalışmanın amacı NAYKH evrelerinde ve sağlıklı bireylerde NLR'nin tanı değerini araştırmaktır.
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Sonuç & Katkı:Bulgular: Hastalık evreleri ilerledikçe (G3), MPV değerlerinde anlamlı bir azalma (p=0,005*) ve NLR değerlerinde anlamlı bir artış (p 0,05), MCH (p>0,05), PDW (p>0,05), PCT (p>0,05), MONO (p>0,05) ve EO (p>0,05) parametrelerinde istatistiksel olarak anlamlı bir fark bulunmamıştır.
🔬Tür:Research Article
📍Kapsam:48 hasta
⚙️Değişkenler:Non-Alcoholic Fatty Liver Disease · Neutrophil · Lymphocyte

Özet

Giriş: Non-alkolik yağlı karaciğer hastalığı (NAYKH), karaciğerde anormal düzeyde yağ birikimi ve buna eşlik eden enflamasyonla karakterize kronik bir durumdur. Bu çalışmanın amacı NAYKH evrelerinde ve sağlıklı bireylerde NLR'nin tanı değerini araştırmaktır. Yöntem: NAYKH Evre 1'li 49 NAYKH hasta, NAYKH Evre 2'li 48 hasta, NAYKH Evre 3'lü 52 hasta ve 103 sağlıklı kontrol bireyi içeren retrospektif bir vaka kontrol çalışması olarak yürütüldü. Nötrofil/Lenfosit oranları ve RBC, HGB, HCT, MCHC, MPV, WBC, NEUT#, RDW-CV, BASO%, MCH, LYMPH%, PDW, PCT, NLR, EO%, RDW-SD, MONO%, PLT, MCV değerleri incelendi. Bulgular: Hastalık evreleri ilerledikçe (G3), MPV değerlerinde anlamlı bir azalma (p=0,005*) ve NLR değerlerinde anlamlı bir artış (p 0,05), MCH (p>0,05), PDW (p>0,05), PCT (p>0,05), MONO (p>0,05) ve EO (p>0,05) parametrelerinde istatistiksel olarak anlamlı bir fark bulunmamıştır. Sonuç: MPV ve NLR, NAYKH'nin ilerlemesini izlemek ve hastaların inflamatuar durumunu değerlendirmek için etkili biyobelirteçler olarak düşünülebilir.

Abstract

Introducton: Non-alcoholic fatty liver disease (NAFLD) is a chronic condition characterized by excessive fat accumulation in the liver accompanied by inflammation. This study aims to know the diagnostic value of NLR in stages of NAFLD Methods: A retrospective case-control study was conducted, including 49 NAFLD patients with NAFLD Grade 1, 48 with NAFLD Grade 2, 52 with NAFLD Grade 3, and 103 healthy control (HC) individuals. Neutrophil/Lymphocyte ratios as well as RBC, HGB, HCT, MCHC, MPV, WBC, MCV, MCH, PLT, RDW-SD, RDW-CV, PDW, PCT, NEUT#, LYMPH%, NLR, MONO%, EO%, BASO% values were examined. Results: As the disease stages progressed (G3), a significant decrease (p=0.005*) in MPV values and a significant increase (p 0.05), MCH (p>0.05), PDW (p>0.05), PCT (p>0.05), MONO (p>0.05) and EO (p>0.05) parameters. Conclusion: MPV and NLR may be considered as effective biomarkers for monitoring the progression of NAFLD and evaluating the inflammatory status of patients.

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Bu Makaleye Atıf Yap

Gül, M. A., Yılmaz, D. T., Çapraz, M. (2025). Alkolik Olmayan Yağlı Karaciğer Hastalığının Evrelerinde Enflamasyon Oranlarının (Nötrofil/Lenfosit) ve Hemogram Sonuçlarının Araştırılması. Meandros Medical And Dental Journal, Volume: 26 Issue: 1. https://doi.org/10.69601/meandrosmdj.1614618

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