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Dergiler / Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi / 2026 / Cilt: 7 Sayı: 1

Acetamiprid ve Propinebin Kombine Etkilerinin in Vivo Değerlendirilmesi

Assessment of the Combined Effects of Acetamiprid and Propineb in Vivo

Pınar Göç Rasgele
Sayfa
79–86
Yayın Tarihi
2017-03-31
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Fakat DNA hasarının farklı seviyelerini ölçen ilave in vivo ve in vitro mutajenite çalışmaları yapılması gereklidir.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Pestisitler tarımda yaygın olarak kullanılan kimyasallardır ve önemli çevre kirleticilerindendirler.
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Temel Bulgular & Veri:Bu çalışmada Acetamiprid ve Propineb pestisit karışımlarının genotoksik etkilerinin in vivo araştırılması amaçlanmıştır.
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Sonuç & Katkı:Fakat DNA hasarının farklı seviyelerini ölçen ilave in vivo ve in vitro mutajenite çalışmaları yapılması gereklidir.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Fare kemik iliği · mikronukleus yöntemi · mutajenite

Özet

Pestisitler tarımda yaygın olarak kullanılan kimyasallardır ve önemli çevre kirleticilerindendirler. Acetamiprid ve Propineb ürünlerde görülen fungal hastalıkları ve entomolojik patojenleri kontrol etmek için yaygın olarak kullanılırlar. Bu çalışmada Acetamiprid ve Propineb pestisit karışımlarının genotoksik etkilerinin in vivo araştırılması amaçlanmıştır. Acetamiprid+Propineb karışımının tüm konsantrasyonlarının 24 ve 48 saatlik muamelelerde konsantrasyonlara bağlı olarak mikronukleuslu polikromatik eritrosit (MNPCE) frekansını arttırdığı gözlendi. Fakat bu artışlar anlamlı bulunmamışlardır. Acetamiprid ve Propineb’in fare kemik iliği hücreleri üzerine olan kombine etkisinin MNPCE yüzdesi bakımından antagonistik olduğu bulunmuştur. Ayrıca, Acetamiprid ve Propineb karışımı polikromatik eritrosit/normokromatik eritrosit (PCE/NCE) oranını tüm konsantrasyonlarda anlamlı olarak azaltmıştır. Çalışmanın sonuçları Acetamiprid’in non-genotoksik olduğunu, Acetamiprid ve Propineb karışımının fare kemik iliği hücreleri için sitotoksik etkilere sahip olabileceğini göstermiştir. Fakat DNA hasarının farklı seviyelerini ölçen ilave in vivo ve in vitro mutajenite çalışmaları yapılması gereklidir.

Abstract

Pesticides are among commonly used chemicals in agriculture and are one of major environmental pollutants. Acetamiprid and Propineb are widely used to control sucking insects and fungal infections on crops, respectively. The study presented aimed to research genotoxic effects of mixture of Acetamiprid and Propineb, in vivo. It was observed that mixture of Acetamiprid+Propineb increases the frequency of micronucleated polychromatic erythrocytes (MNPCE) at all concentrations for 24 and 48 h depending on concentrations. But these increases were not signifcant. The combined effect of the Acetamiprid and Propineb on bone marrow cells of mice in vivo was found to be antagonistic in terms of percentage of MNPCE. In addition, mixture of Acetamiprid and Propineb signifcantly decreased polychromatic erythrocytes/normochromatic erythrocytes (PCE/NCE) ratio at all concentrations. The results of the present investigation revealed that Acetamiprid was non-genotoxic, while mixture of the Acetamiprid and Propineb may have cytotoxic effects for mice bone marrow cells. But, additional in vivo and in vitro mutagenicity studies measuring different levels of DNA damage are still necessary.

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Bu Makaleye Atıf Yap

Rasgele, P. G. (2017). Acetamiprid ve Propinebin Kombine Etkilerinin in Vivo Değerlendirilmesi. Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi, Cilt: 7 Sayı: 1, 79–86. https://ajindex.com/articles/1273055

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