KaydedilenlerDerginizi ekleyin

Dergiler / Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi / 2026 / Cilt: 8 Sayı: 2

Bisfenol A’nın Sıçan İnce Bağırsak Dokusunda Oluşturduğu Histopatolojik Değişiklikler Üzerine Taurin ve Kurkumin’in Koruyucu Rolü

Bisphenol A-Induced Histopathological Alterations on Small Intestine Tissues of Rats: The Protective Role of Taurine and Curcumin

Fatma Gökçe Apaydın0000-0002-2771-7488
Meltem Uzunhisarcıklı0000-0003-1265-8347
Ayşe Aslantürk0000-0002-4737-702X
Suna Kalender0000-0002-9654-1287
Sayfa
43–47
Yayın Tarihi
2018-06-30
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bu çalışmanın amacı, BPA’nın sıçan

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Bisfenol A (BPA) endokrin bozucu özelliğe sahip bir kimyasaldır.
📊
Temel Bulgular & Veri:Bisfenol A (BPA) endokrin bozucu özelliğe sahip bir kimyasaldır.
💡
Sonuç & Katkı:Bu çalışmanın amacı, BPA’nın sıçan
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Bisfenol A · histopatoloji · ince bağırsak

Özet

Bisfenol A (BPA) endokrin bozucu özelliğe sahip bir kimyasaldır. Bu çalışmanın amacı, BPA’nın sıçan

Abstract

Bisphenol A (BPA) has endocrine-disrupting properties. The present study aimed to examine the possible protective roles of curcumin and taurine against BPA-induced small intestine toxicity in rats. For this purpose, forty-two adult albino male rats were divided seven equal groups: control, olive oil, curcumin (100 mg kg-1 daily), taurine (100 mg kg-1 daily), BPA (130 mg kg-1 daily), curcumin+BPA, taurine+BPA. After four weeks on treatment small intestine tissues were examined for histopathological examinations. BPA caused seriously toxicity on small intestine tissues, but curcumin and taurine did not have completely protective effects of this damage.

🔖

Bu Makaleye Atıf Yap

Apaydın, F. G., Uzunhisarcıklı, M., Aslantürk, A., Kalender, S. (2018). Bisfenol A’nın Sıçan İnce Bağırsak Dokusunda Oluşturduğu Histopatolojik Değişiklikler Üzerine Taurin ve Kurkumin’in Koruyucu Rolü. Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi, Cilt: 8 Sayı: 2, 43–47. https://doi.org/10.21597/jist.427870

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (19)

  1. Akinyemi AJ, Oboh G, Fadaka AO, Olatunji BP, Akomolafe S, 2017. Curcumin administration suppress acetylcholinesterase gene expression in cadmium treated rats. Neurotoxicology, 62: 75-79.
  2. Apaydın FG, Bas H, Kalender S, Kalender Y, 2017. Bendiocarb induced histopathological and biochemical alterations in rat liver and preventive role of vitamins C and E. Environmental Toxicology and Pharmacology, 49: 148–155.
  3. Eid JI, Eissa SM, El-Ghor, AA, 2015. Bispheol A induces oxidative stress and DNA damage in hepatic tissue of female rat offspring. The Journal of Basic and Applied Zoology, 71:10-19.
  4. El-Missiry MA, Othman AI, Al-Abdan, MA, Sayed, AA, 2014. Melatonin ameliorates oxidative stress, modulates death receptor pathway proteins, and protects the rat cerebrum against Bisphenol-A-induced apoptosis. Journal of the Neurological Sciences, 347: 251–256.
  5. Feng Y, Sun F, Gao Y, Yang J, Wu G, Lin S, Hu J, 2017. Taurine decreased uric acid levels in hyperuricemic rats and alleviated kidney injury. Biochemical and Biophysical Research Communications, 489: 312-318.
  6. Hassan ZK, Elobeid MA, Virk P, Omer SA, El Amin M, Daghestani MH, AlOyan EM, 2012. Bisphenol A induces hepatotoxicity through oxidative stress in rat model. Oxidative Medicine and Cellular Longevity, 2012: 194829.
  7. Kalender S, Apaydın FG, Demir F, Bas H, 2014. Lead nitrate induced oxidative stress in brain tissues of rats: protective effect of sodium selenite. Gazi University Journal of Science, 27(3): 883-889.
  8. Learn DB, Fried VA, Thomas EL, 1990. Taurine and hypotaurine content of human leukocytes. Journal of Leukocyte Biology, 48: 174–182.
  9. Mahmoudi A, Ghorbel H, Bouallegui Z, Marrekchi R, Isoda H, Sayadi S, 2015. Oleuropein and hydroxytyrosol protect from bisphenol A effects in livers and kidneys of lactating mother rats and their pups. Experimental and Toxicologic Pathology, 67: 413-425.
  10. Michalowicz J, 2014. Bisphenol A-Sources, toxicity and biotransformation. Environmental Toxicology and Pharmacology, 27: 738-758.
  11. Murakami S, 2017. The physiological and pathophysiological roles of taurine in adipose tissue in relation to obesity. Life Sciences, 186: 80-86.
  12. Ortiz-Villanueva E, Navarro-Martín L, Jaumot J, Benavente F, Sanz-Nebot V, Pina, B, Tauler R, 2017. Metabolic disruption of zebrafish (Danio rerio) embryos by bisphenol A. An integrated metabolomic and transcriptomic approach. Environmental Pollution, 231: 22-36.
  13. Sanmukhani J, Satodia V, Trivedi J, Patel T, Tiwari D, Panchal B, Goel A, Tripathi CB, 2014. Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial. Phytotherapy Research, 28: 579-585.
  14. Shirpoor A, Barmaki H, Ansari MK, Ikhanizadeh B, Barmaki H, 2016. Protective effect of vitamin E against ethanol-induced small intestine damage in rats. Biomedicine & Pharmacotherapy, 78: 150–155.
  15. Tarapore P, Hennesy M, Song D, Ying J, Outang B, Govindarajah V, Leung Y, Ho S, 2017. High butter-fat diet and bisphenol A additively impair male ratspermatogenesis. Reproductive Toxicology, 68: 191–199.
  16. Verhagen H, Buijsse B, Jansen E, Bueno-de-Mesquita B, 2006. The state of antioxidant affairs, Nutrition Today, 41(6): 244-250.
  17. Wang Y, Yuan J, Lu W, Li B, Xu D, 2015. Taurine zinc solid dispersions attenuate doxorubicin-induced hepatotoxicity and cardiotoxicity in rats. Toxicology and Applied Pharmacology, 289: 1–11.
  18. Zhang H, Huang X, Sun J, Yamamoto A, Gao Y, 2017. Enhanced pulmonary bioavailability of curcumin by some common excipients and relative therapeutic effects on sepsis-induced acute lung injury in rats. Journal of Drug Delivery Science and Technology, 41: 231-238.
  19. Zhou Y, Wang Z, Xia M, Zhuang S, Gong X, Pan J, Li C, Fan R, Pang Q, Lu S, 2017. Neurotoxicity of low bisphenol A (BPA) exposure for young male mice: Implications for children exposed to environmental levels of BPA. Environmental Pollution, 229: 40-48.